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RTK signaling

激活刺激包括过多的生长因子、激素和细胞因子。大多数RTKs会在配体结合时发生二聚化并变得活跃。活化的RTK则可磷酸化多种下游信号级联反应的激活剂,如NF-kB、MAPK、Ca2+依赖信号转导以及JAK-STAT通路。因此,RTKs可影响从细胞骨架动力学、细胞生长和分化到炎症、细胞凋亡和肿瘤进展等广泛过程。尽管受体及结局多种多样,但是RTKs实际上只参与有限的核心过程。因此,诸如RTK表达上限等因子定量分析对理解信号传导过程和预测定性结局都是至关重要的。

Ligand

ANGPT1 - Angiopoietin 1

Involved in the conversion of lanosterol to cholesterol.   更多...

ANGPT2 - Angiopoietin 2

The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].   更多...

BDNF (Brain-Derived Neurotrophic Factor):

The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants...   更多...

Figf - FIGF

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is...   更多...

COL11A2 (Collagen, Type XI, alpha 2):

This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a...   更多...

EGF (Epidermal Growth Factor):

This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by...   更多...

FGF6 (Fibroblast Growth Factor 6):

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into...   更多...

FGF7 (Fibroblast Growth Factor 7):

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose...   更多...

GDNF (Glial Cell Derived Neurotrophic Factor):

This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the...   更多...

LGALS3 - Galectin 3

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent...   更多...

MDK (Midkine (Neurite Growth-Promoting Factor 2)):

This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been...   更多...

NGFB (Nerve Growth Factor beta):

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic...   更多...

PDGFD (Platelet Derived Growth Factor D):

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs...   更多...

TUB (Tubby Homolog (Mouse)):

This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants...   更多...
此分类里的别的抗原:
ATF2 (Activating Transcription Factor 2): ATF2 抗体 ATF2 ELISA试剂盒 ATF2 蛋白
AREG - Amphiregulin: AREG 抗体 AREG ELISA试剂盒 AREG 蛋白
ANGPT4 - Angiopoietin 4: ANGPT4 抗体 ANGPT4 ELISA试剂盒 ANGPT4 蛋白
BTC - Betacellulin: BTC 抗体 BTC ELISA试剂盒 BTC 蛋白
CSF1 (Colony Stimulating Factor 1 (Macrophage)): CSF1 抗体 CSF1 ELISA试剂盒 CSF1 蛋白
EFNA1 - Ephrin A1: EFNA1 抗体 EFNA1 ELISA试剂盒 EFNA1 蛋白
EFNA3 - Ephrin A3: EFNA3 抗体 EFNA3 ELISA试剂盒 EFNA3 蛋白
EFNA4 (Ephrin A4): EFNA4 抗体 EFNA4 ELISA试剂盒 EFNA4 蛋白
EFNA5 - Ephrin A5: EFNA5 抗体 EFNA5 ELISA试剂盒 EFNA5 蛋白
EFNB1 - Ephrin B1: EFNB1 抗体 EFNB1 ELISA试剂盒 EFNB1 蛋白
EFNB2 - Ephrin B2: EFNB2 抗体 EFNB2 ELISA试剂盒 EFNB2 蛋白
EFNB3 - Ephrin B3: EFNB3 抗体 EFNB3 ELISA试剂盒 EFNB3 蛋白
EREG - Epiregulin: EREG 抗体 EREG ELISA试剂盒 EREG 蛋白
EPGN (Epithelial Mitogen Homolog (Mouse)): EPGN 抗体 EPGN ELISA试剂盒 EPGN 蛋白
FGF1 (Fibroblast Growth Factor 1 (Acidic)): FGF1 抗体 FGF1 ELISA试剂盒 FGF1 蛋白
FGF10 (Fibroblast Growth Factor 10): FGF10 抗体 FGF10 ELISA试剂盒 FGF10 蛋白
FGF19 (Fibroblast Growth Factor 19): FGF19 抗体 FGF19 ELISA试剂盒 FGF19 蛋白
FGF2 (Fibroblast Growth Factor 2 (Basic)): FGF2 抗体 FGF2 ELISA试剂盒 FGF2 蛋白
FGF21 (Fibroblast Growth Factor 21): FGF21 抗体 FGF21 ELISA试剂盒 FGF21 蛋白
FGF22 (Fibroblast Growth Factor 22): FGF22 抗体 FGF22 ELISA试剂盒 FGF22 蛋白
FGF23 (Fibroblast Growth Factor 23): FGF23 抗体 FGF23 ELISA试剂盒 FGF23 蛋白
FGF3 (Fibroblast Growth Factor 3): FGF3 抗体 FGF3 ELISA试剂盒 FGF3 蛋白
FGF4 (Fibroblast Growth Factor 4): FGF4 抗体 FGF4 ELISA试剂盒 FGF4 蛋白
FGF5 (Fibroblast Growth Factor 5): FGF5 抗体 FGF5 ELISA试剂盒 FGF5 蛋白
FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced)): FGF8 抗体 FGF8 ELISA试剂盒 FGF8 蛋白
FLT3LG (Fms-Related tyrosine Kinase 3 Ligand): FLT3LG 抗体 FLT3LG ELISA试剂盒 FLT3LG 蛋白
GDNF (Glial Cell Line Derived Neurotrophic Factor): GDNF 抗体 GDNF ELISA试剂盒 GDNF 蛋白
GAS6 (Growth Arrest-Specific 6): GAS6 抗体 GAS6 ELISA试剂盒 GAS6 蛋白
HBEGF (Heparin-Binding EGF-Like Growth Factor): HBEGF 抗体 HBEGF ELISA试剂盒 HBEGF 蛋白
HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor)): HGF 抗体 HGF ELISA试剂盒 HGF 蛋白
INS - Insulin: INS 抗体 INS ELISA试剂盒 INS 蛋白
IGF1 (Insulin-Like Growth Factor 1): IGF1 抗体 IGF1 ELISA试剂盒 IGF1 蛋白
IL34 (Interleukin 34): IL34 抗体 IL34 ELISA试剂盒 IL34 蛋白
KITLG - KIT Ligand: KITLG 抗体 KITLG ELISA试剂盒 KITLG 蛋白
NRG1 - Neuregulin 1: NRG1 抗体 NRG1 ELISA试剂盒 NRG1 蛋白
NRG2 - Neuregulin 2: NRG2 抗体 NRG2 ELISA试剂盒 NRG2 蛋白
NRG3 - Neuregulin 3: NRG3 抗体 NRG3 ELISA试剂盒 NRG3 蛋白
NRG4 - Neuregulin 4: NRG4 抗体 NRG4 ELISA试剂盒 NRG4 蛋白
NTF3 - Neurotrophin 3: NTF3 抗体 NTF3 ELISA试剂盒 NTF3 蛋白
NTF4 - Neurotrophin 4: NTF4 抗体 NTF4 ELISA试剂盒 NTF4 蛋白
PDGFBB (Platelet Derived Growth Factor BB): PDGFBB 抗体 PDGFBB ELISA试剂盒 PDGFBB 蛋白
PDGFA (Platelet-Derived Growth Factor alpha Polypeptide): PDGFA 抗体 PDGFA ELISA试剂盒 PDGFA 蛋白
PDGFB (Platelet-Derived Growth Factor beta Polypeptide): PDGFB 抗体 PDGFB ELISA试剂盒 PDGFB 蛋白
PDGFC (Platelet-Derived Growth Factor C): PDGFC 抗体 PDGFC ELISA试剂盒 PDGFC 蛋白
PTN - Pleiotrophin: PTN 抗体 PTN ELISA试剂盒 PTN 蛋白
TGFA (Transforming Growth Factor, alpha): TGFA 抗体 TGFA ELISA试剂盒 TGFA 蛋白
TULP1 (Tubby Like Protein 1): TULP1 抗体 TULP1 ELISA试剂盒 TULP1 蛋白
VEGFA - VEGF: VEGFA 抗体 VEGFA ELISA试剂盒 VEGFA 蛋白
VEGFB (Vascular Endothelial Growth Factor B): VEGFB 抗体 VEGFB ELISA试剂盒 VEGFB 蛋白
VEGFC (Vascular Endothelial Growth Factor C): VEGFC 抗体 VEGFC ELISA试剂盒 VEGFC 蛋白

RTK

TYRO3 (TYRO3 Protein Tyrosine Kinase):

The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified...   更多...

AATK (Apoptosis-Associated tyrosine Kinase):

The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell...   更多...

AXL (AXL Receptor tyrosine Kinase):

The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein...   更多...

MERTK (C-Mer Proto-Oncogene Tyrosine Kinase):

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis...   更多...

EPHA3 - EPH Receptor A3

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors...   更多...

EPHA4 - EPH Receptor A4

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors...   更多...

EPHA5 - EPH Receptor A5

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors...   更多...

Epha6 - EPH Receptor A6

Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).   更多...

EPHA8 - EPH Receptor A8

This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin...   更多...

FGFR1 (Fibroblast Growth Factor Receptor 1):

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like...   更多...

FGFR2 (Fibroblast Growth Factor Receptor 2):

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like...   更多...

INSR - Insulin Receptor

After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].   更多...

MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase)):

This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated...   更多...

NTRK1 - TRKA

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding...   更多...

NTRK2 - TRKB

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants...   更多...

KIT (V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog):

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia,...   更多...
此分类里的别的抗原:
ALK (Anaplastic Lymphoma Receptor tyrosine Kinase): ALK 抗体 ALK ELISA试剂盒  
AXL - AXL Receptor Tyrosine Kinase: AXL 抗体    
ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase): ROS1 抗体 ROS1 ELISA试剂盒 ROS1 蛋白
CSF1R (Colony Stimulating Factor 1 Receptor): CSF1R 抗体 CSF1R ELISA试剂盒 CSF1R 蛋白
DDR1 - MCK10: DDR1 抗体   DDR1 蛋白
DDR1 (Discoidin Domain Receptor tyrosine Kinase 1): DDR1 抗体 DDR1 ELISA试剂盒 DDR1 蛋白
DDR2 (Discoidin Domain Receptor tyrosine Kinase 2): DDR2 抗体 DDR2 ELISA试剂盒 DDR2 蛋白
EPHA10 - EPH Receptor A10: EPHA10 抗体 EPHA10 ELISA试剂盒 EPHA10 蛋白
EPHA2 - EPH Receptor A2: EPHA2 抗体 EPHA2 ELISA试剂盒 EPHA2 蛋白
EPHA7 - EPH Receptor A7: EPHA7 抗体 EPHA7 ELISA试剂盒 EPHA7 蛋白
EPHB1 - EPH Receptor B1: EPHB1 抗体 EPHB1 ELISA试剂盒 EPHB1 蛋白
EPHB2 - EPH Receptor B2: EPHB2 抗体 EPHB2 ELISA试剂盒 EPHB2 蛋白
EPHB3 - EPH Receptor B3: EPHB3 抗体 EPHB3 ELISA试剂盒 EPHB3 蛋白
EPHB4 - EPH Receptor B4: EPHB4 抗体 EPHB4 ELISA试剂盒 EPHB4 蛋白
EPHB6 - EPH Receptor B6: EPHB6 抗体 EPHB6 ELISA试剂盒 EPHB6 蛋白
EGFR (Epidermal Growth Factor Receptor): EGFR 抗体 EGFR ELISA试剂盒 EGFR 蛋白
FGFR3 (Fibroblast Growth Factor Receptor 3): FGFR3 抗体 FGFR3 ELISA试剂盒 FGFR3 蛋白
FGFR4 (Fibroblast Growth Factor Receptor 4): FGFR4 抗体 FGFR4 ELISA试剂盒 FGFR4 蛋白
FGFRL1 (Fibroblast Growth Factor Receptor-Like 1): FGFRL1 抗体 FGFRL1 ELISA试剂盒 FGFRL1 蛋白
FLT1 (Fms-Related tyrosine Kinase 1 (Vascular Endothelial Growth Factor/vascular Permeability Factor Receptor)): FLT1 抗体 FLT1 ELISA试剂盒 FLT1 蛋白
FLT3 (Fms-Related tyrosine Kinase 3): FLT3 抗体 FLT3 ELISA试剂盒 FLT3 蛋白
FLT4 (Fms-Related Tyrosine Kinase 4): FLT4 抗体 FLT4 ELISA试剂盒 FLT4 蛋白
INSRR (Insulin Receptor-Related Receptor): INSRR 抗体 INSRR ELISA试剂盒 INSRR 蛋白
IGF1R (Insulin-Like Growth Factor 1 Receptor): IGF1R 抗体 IGF1R ELISA试剂盒 IGF1R 蛋白
IGF1R (Insulin-Like Growth Factor I Receptor): IGF1R 抗体 IGF1R ELISA试剂盒  
KDR - VEGFR2: KDR 抗体 KDR ELISA试剂盒 KDR 蛋白
LMTK2 (Lemur tyrosine Kinase 2): LMTK2 抗体 LMTK2 ELISA试剂盒 LMTK2 蛋白
LTK (Leukocyte Receptor tyrosine Kinase): LTK 抗体 LTK ELISA试剂盒 LTK 蛋白
KIT (Mast/stem Cell Growth Factor Receptor): KIT 抗体 KIT ELISA试剂盒 KIT 蛋白
MME (Membrane Metallo-Endopeptidase): MME 抗体 MME ELISA试剂盒 MME 蛋白
MET (Met Proto-Oncogene (Hepatocyte Growth Factor Receptor)): MET 抗体 MET ELISA试剂盒  
MET (Met Proto-Oncogene): MET 抗体 MET ELISA试剂盒 MET 蛋白
MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase): MUSK 抗体 MUSK ELISA试剂盒 MUSK 蛋白
NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3): NTRK3 抗体 NTRK3 ELISA试剂盒 NTRK3 蛋白
PDGFRA (Platelet-Derived Growth Factor Receptor, alpha Polypeptide): PDGFRA 抗体 PDGFRA ELISA试剂盒 PDGFRA 蛋白
KCNH8 (Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 8): KCNH8 抗体 KCNH8 ELISA试剂盒 KCNH8 蛋白
PTK7 (PTK7 Protein tyrosine Kinase 7): PTK7 抗体 PTK7 ELISA试剂盒 PTK7 蛋白
ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1): ROR1 抗体 ROR1 ELISA试剂盒 ROR1 蛋白
ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2): ROR2 抗体 ROR2 ELISA试剂盒 ROR2 蛋白
RET - Ret Proto-Oncogene: RET 抗体 RET ELISA试剂盒 RET 蛋白
RYK (RYK Receptor-Like Tyrosine Kinase): RYK 抗体 RYK ELISA试剂盒 RYK 蛋白
TEK (TEK Tyrosine Kinase, Endothelial): TEK 抗体 TEK ELISA试剂盒 TEK 蛋白
TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1): TIE1 抗体 TIE1 ELISA试剂盒 TIE1 蛋白
ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian)): ERBB4 抗体 ERBB4 ELISA试剂盒 ERBB4 蛋白
ERBB2 - HER2: ERBB2 抗体 ERBB2 ELISA试剂盒 ERBB2 蛋白
ERBB3 (V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian)): ERBB3 抗体 ERBB3 ELISA试剂盒 ERBB3 蛋白
VGFR3 (VGFR3): VGFR3 抗体    

Adaptors

SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1):

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the...   更多...

SHC2 (SHC (Src Homology 2 Domain Containing) Transforming Protein 2):

predicted to be a member of the Shc family of adaptor proteins that bind to receptor tyrosine kinases and mediate cell signalling [RGD, Feb 2006].   更多...
此分类里的别的抗原:
GAB1 (GRB2-Associated Binding Protein 1): GAB1 抗体    
GRB2 (Growth Factor Receptor-Bound Protein 2): GRB2 抗体 GRB2 ELISA试剂盒 GRB2 蛋白
SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3): SHC3 抗体 SHC3 ELISA试剂盒 SHC3 蛋白

GEF

RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1):

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic...   更多...

SOS1 (Son of Sevenless Homolog 1 (Drosophila)):

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with...   更多...
此分类里的别的抗原:
RAPGEF5 - GFR: RAPGEF5 抗体 RAPGEF5 ELISA试剂盒 RAPGEF5 蛋白
SOS2 (Son of Sevenless Homolog 2 (Drosophila)): SOS2 抗体 SOS2 ELISA试剂盒 SOS2 蛋白

GTPase

RHOG (Ras Homolog Family Member G):

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide...   更多...

RAC2 (Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2)):

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. [provided by RefSeq, Jul 2008].   更多...
此分类里的别的抗原:
CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa)): CDC42 抗体 CDC42 ELISA试剂盒 CDC42 蛋白
NRAS - GTPase NRas: NRAS 抗体 NRAS ELISA试剂盒 NRAS 蛋白
HRAS - Harvey Rat Sarcoma Viral Oncogene Homolog: HRAS 抗体    
RAC3 (Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP Binding Protein Rac3)): RAC3 抗体 RAC3 ELISA试剂盒 RAC3 蛋白
HRAS (V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog): HRAS 抗体 HRAS ELISA试剂盒 HRAS 蛋白

Inhibitor

DEPTOR (DEP Domain Containing MTOR-Interacting Protein):

Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes (By similarity).   更多...

TSC1 (Tuberous Sclerosis 1):

This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009].   更多...

TSC2 (Tuberous Sclerosis 2):

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].   更多...

Kinase

MAPK1 - ERK2

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its...   更多...

MAPK3 (Mitogen-Activated Protein Kinase 3):

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its...   更多...

PAK1 (P21-Activated Kinase 1):

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript...   更多...

PAK2 (P21-Activated Kinase 2):

The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic...   更多...

PAK4 (P21-Activated Kinase 4):

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the...   更多...

AKT1 - AKT

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through...   更多...

AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2):

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded...   更多...

AKT3 (V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma)):

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake....   更多...
此分类里的别的抗原:
FRAP1 - MTOR: FRAP1 抗体 FRAP1 ELISA试剂盒 FRAP1 蛋白
MAP2K1 (Mitogen-Activated Protein Kinase Kinase 1): MAP2K1 抗体 MAP2K1 ELISA试剂盒 MAP2K1 蛋白
MAP2K2 (Mitogen-Activated Protein Kinase Kinase 2): MAP2K2 抗体 MAP2K2 ELISA试剂盒 MAP2K2 蛋白
PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide): PIK3CA 抗体 PIK3CA ELISA试剂盒 PIK3CA 蛋白
PIK3CG (Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide): PIK3CG 抗体 PIK3CG ELISA试剂盒 PIK3CG 蛋白
PRKCZ - PKC zeta: PRKCZ 抗体 PRKCZ ELISA试剂盒 PRKCZ 蛋白
PDK1 (Pyruvate Dehydrogenase Kinase, Isozyme 1): PDK1 抗体 PDK1 ELISA试剂盒 PDK1 蛋白
PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2): PDK2 抗体 PDK2 ELISA试剂盒 PDK2 蛋白
RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1): RPS6KB1 抗体 RPS6KB1 ELISA试剂盒 RPS6KB1 蛋白
RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2): RPS6KB2 抗体 RPS6KB2 ELISA试剂盒 RPS6KB2 蛋白

Messenger

CALM - Calmodulin

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.   更多...
此分类里的别的抗原:
CALM1 - Calmodulin 1 (Phosphorylase Kinase, Delta): CALM1 抗体 CALM1 ELISA试剂盒 CALM1 蛋白
Calm2 - Calmodulin 2 (phosphorylase Kinase, Delta): Calm2 抗体   Calm2 蛋白
CALM3 (Calmodulin 3 (Phosphorylase Kinase, Delta)): CALM3 抗体 CALM3 ELISA试剂盒 CALM3 蛋白

Phosphatase

PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isozyme):

catalytic subunit of Calcineurin (CaN), ubiquitously expressed Ca2+/CaM-dependent protein phosphatase\; mediates activities of transcription factors and ion channels\; involved in regulation of T-cell activation [RGD, Feb 2006].   更多...

PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11):

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the...   更多...
此分类里的别的抗原:
PPP3CB (Protein Phosphatase 3, Catalytic Subunit, beta Isozyme): PPP3CB 抗体 PPP3CB ELISA试剂盒 PPP3CB 蛋白
PPP3CC (Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme): PPP3CC 抗体 PPP3CC ELISA试剂盒 PPP3CC 蛋白
PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha): PPP3R1 抗体 PPP3R1 ELISA试剂盒 PPP3R1 蛋白

Phospholipase

PLCG2 - Phospholipase C gamma 2

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the...   更多...

PLCG1 - Phospholipase C gamma 1

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide...   更多...

PLD2 - Phospholipase D2

The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or...   更多...

Pro-apoptotic

BAD (BCL2-Associated Agonist of Cell Death):

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase,...   更多...

Protease

CASP9 - Caspase 9

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed...   更多...

Protein kinase

IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta):

The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011].   更多...

JAK1 (Janus Kinase 1):

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members....   更多...

JAK2 (Janus Kinase 2):

This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis....   更多...
此分类里的别的抗原:
CHUK (conserved Helix-Loop-Helix Ubiquitous Kinase): CHUK 抗体 CHUK ELISA试剂盒 CHUK 蛋白
IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma): IKBKG 抗体 IKBKG ELISA试剂盒 IKBKG 蛋白
JAK3 (Tyrosine-Protein Kinase JAK3): JAK3 抗体 JAK3 ELISA试剂盒 JAK3 蛋白
ARAF (V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog): ARAF 抗体 ARAF ELISA试剂盒 ARAF 蛋白
BRAF (V-Raf Murine Sarcoma Viral Oncogene Homolog B1): BRAF 抗体 BRAF ELISA试剂盒 BRAF 蛋白
RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1): RAF1 抗体 RAF1 ELISA试剂盒 RAF1 蛋白

Regulator

EIF4EBP1 (Eukaryotic Translation Initiation Factor 4E Binding Protein 1):

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is...   更多...

MLST8 (MTOR Associated Protein, LST8 Homolog (S. Cerevisiae)):

cytosolic protein similar to an insulin receptor [RGD, Feb 2006].   更多...

RHEB (Ras Homolog Enriched in Brain):

This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and...   更多...

Transcription factor

JUN - C-JUN

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul...   更多...

NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1):

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in...   更多...

NFkBP65 - p65

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is...   更多...

STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa):

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha,...   更多...

STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor)):

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and...   更多...
此分类里的别的抗原:
NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive): NFAT5 抗体 NFAT5 ELISA试剂盒 NFAT5 蛋白
NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2): NFAT1 抗体 NFAT1 ELISA试剂盒 NFAT1 蛋白
NFATC3 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3): NFATC3 抗体 NFATC3 ELISA试剂盒 NFATC3 蛋白
NFATC4 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4): NFATC4 抗体 NFATC4 ELISA试剂盒 NFATC4 蛋白
NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1): NFKB1 抗体 NFKB1 ELISA试剂盒 NFKB1 蛋白
NFKB2 - Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2: NFKB2 抗体 NFKB2 ELISA试剂盒  
STAT5A (Signal Transducer and Activator of Transcription 5A): STAT5A 抗体 STAT5A ELISA试剂盒 STAT5A 蛋白
STAT5B (Signal Transducer and Activator of Transcription 5B): STAT5B 抗体 STAT5B ELISA试剂盒 STAT5B 蛋白
RELB - V-Rel Reticuloendotheliosis Viral Oncogene Homolog B: RELB 抗体 RELB ELISA试剂盒 RELB 蛋白

Others

ABI1 (Abl-Interactor 1):

This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a...   更多...

ARPC1B (Actin Related Protein 2/3 Complex, Subunit 1B, 41kDa):

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is...   更多...

ACTR2 (ARP2 Actin-Related Protein 2 Homolog (Yeast)):

The specific function of this gene has not yet been determined\; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by...   更多...

NCKAP1 (NCK Associated Protein 1):

interacts with Nck and may be involved in the downstream signaling of Nck [RGD, Feb 2006].   更多...
此分类里的别的抗原:
CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2): CYFIP2 抗体   CYFIP2 蛋白
ARPC2 (Actin Related Protein 2/3 Complex, Subunit 2, 34kDa): ARPC2 抗体 ARPC2 ELISA试剂盒 ARPC2 蛋白
ARPC3 (Actin Related Protein 2/3 Complex, Subunit 3, 21kDa): ARPC3 抗体 ARPC3 ELISA试剂盒 ARPC3 蛋白
ARPC4 (Actin Related Protein 2/3 Complex, Subunit 4, 20kDa): ARPC4 抗体 ARPC4 ELISA试剂盒 ARPC4 蛋白
ARPC5 (Actin Related Protein 2/3 Complex, Subunit 5, 16kDa): ARPC5 抗体 ARPC5 ELISA试剂盒 ARPC5 蛋白
ACTR3 (ARP3 Actin-Related Protein 3 Homolog (Yeast)): ACTR3 抗体 ACTR3 ELISA试剂盒 ACTR3 蛋白
BRK1 (BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit): BRK1 抗体   BRK1 蛋白
RPTOR - Raptor: RPTOR 抗体 RPTOR ELISA试剂盒 RPTOR 蛋白
WASF1 (WAS Protein Family, Member 1): WASF1 抗体 WASF1 ELISA试剂盒 WASF1 蛋白
WASF2 (WAS Protein Family, Member 2): WASF2 抗体 WASF2 ELISA试剂盒 WASF2 蛋白
WASF3 (WAS Protein Family, Member 3): WASF3 抗体 WASF3 ELISA试剂盒 WASF3 蛋白
WIPF1 (WAS/WASL Interacting Protein Family, Member 1): WIPF1 抗体 WIPF1 ELISA试剂盒 WIPF1 蛋白
WASL (Wiskott-Aldrich Syndrome-Like): WASL 抗体 WASL ELISA试剂盒 WASL 蛋白