Neurodegenerative diseases represent a major threat to human health. These age-dependent disorders are becoming increasingly prevalent, in part because the elderly population has increased in recent years. Examples of neurodegenerative diseases are Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, frontotemporal dementia and the spinocerebellar ataxias.
These diseases are diverse in their pathophysiology – with some causing memory and cognitive impairments and others affecting a person's ability to move, speak and breathe. Effective treatments are desperately needed but will only come with a deep understanding of the causes and mechanisms of each disease.(1)
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: "Neurodegenerative disease: models, mechanisms, and a new hope.
" in: Disease models & mechanisms
, Vol. 10
, Issue 5
, pp. 499-502