电话:
+1 877 302 8632
传真:
+1 888 205 9894 (Toll-free)
电子邮件:
orders@antibodies-online.cn

RTK signaling

激活刺激包括过多的生长因子、激素和细胞因子。大多数RTKs会在配体结合时发生二聚化并变得活跃。活化的RTK则可磷酸化多种下游信号级联反应的激活剂,如NF-kB、MAPK、Ca2+依赖信号转导以及JAK-STAT通路。因此,RTKs可影响从细胞骨架动力学、细胞生长和分化到炎症、细胞凋亡和肿瘤进展等广泛过程。尽管受体及结局多种多样,但是RTKs实际上只参与有限的核心过程。因此,诸如RTK表达上限等因子定量分析对理解信号传导过程和预测定性结局都是至关重要的。

Ligand

HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor)):

RTK

MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase)):

ALK (Anaplastic Lymphoma Receptor tyrosine Kinase):

PDGFRA (Platelet-Derived Growth Factor Receptor, alpha Polypeptide):

KCNH8 (Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 8):

PTK7 (PTK7 Protein tyrosine Kinase 7):

TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1):

ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian)):

Adaptors

SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1):

SHC2 (SHC (Src Homology 2 Domain Containing) Transforming Protein 2):

GAB1 (GRB2-Associated Binding Protein 1):

SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3):

GEF

GTPase

RAC2 (Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2)):

RAC3 (Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP Binding Protein Rac3)):

Inhibitor

Kinase

AKT3 (V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma)):

PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide):

Messenger

Phosphatase

PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform):

PPP3CB (Protein Phosphatase 3, Catalytic Subunit, beta Isozyme):

PPP3CC (Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme):

Phospholipase

Pro-apoptotic

Protease

Protein kinase

Regulator

Transcription factor

NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1):

STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa):

STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor)):

NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive):

NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2):

NFATC3 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3):

NFATC4 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4):

NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1):

Others

WIPF1 (WAS/WASL Interacting Protein Family, Member 1):

You are here:
help 客服