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Fc Receptor (FcRn) 抗体 Primary Antibody

适用: 人 cELISA, FACS, ELISA 宿主: 小鼠 Monoclonal ADM31 unconjugated
Pubmed (1)
产品编号 ABIN1774762
$495.00
加上运输费 $45.00
100 μg
local_shipping 发货至: 美国
6至7个工作日
  • 抗原
    Fc Receptor (FcRn)
    适用
    • 1
    • 1
    宿主
    • 1
    小鼠
    克隆类型
    • 1
    单克隆
    应用范围
    Cell-ELISA (cELISA), Flow Cytometry (FACS), ELISA
    产品特性
    based on recognition of the complete native protein expressed on transfected mammalian cells
    纯化方法
    Purified, Protein A
    免疫原
    Antibodies were generated by immunizing mouse FcRn-deficient mice with spleen cells from mice transgenic for human FcRn.
    克隆位点
    ADM31
    亚型
    IgG2b
  • 应用备注
    • Flow cytometry: 1.2 μg/10^6 cells
    • ELISA: 1:200 - 1:400
    • CELISA: 1:200 - 1:400
    For each application a titration should be performed to determine the optimal concentration.
    限制
    仅限研究用
  • 缓冲液
    phosphate buffered saline, pH 7.2
    注意事项
    avoid repeated freezing and thawing
    储存条件
    4 °C
  • Christianson, Sun, Akilesh, Pesavento, Proetzel, Roopenian: "Monoclonal antibodies directed against human FcRn and their applications." in: mAbs, Vol. 4, Issue 2, pp. 208-16, 2014 (PubMed).

  • 抗原
    Fc Receptor (FcRn)
    背景
    The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
    Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT
    UniProt
    P55899
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