Fc Receptor (FcRn) 抗体 Primary Antibody

产品细节 (hide)

抗原

Fc Receptor (FcRn)

适用 All reactivities for Fc Receptor (FcRn) 抗体

• 人 1
• 小鼠 1

人

宿主 All hosts for Fc Receptor (FcRn) 抗体

• 小鼠 1

小鼠

Compatible Secondaries

克隆类型 All clonalities for Fc Receptor (FcRn) 抗体

• 单克隆 1

单克隆

应用范围

Cell-ELISA (cELISA), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

产品特性

based on recognition of the complete native protein expressed on transfected mammalian cells

纯化方法

Purified, Protein A

免疫原

Antibodies were generated by immunizing mouse FcRn-deficient mice with spleen cells from mice transgenic for human FcRn.

克隆位点

ADM31

亚型

IgG2b

Alternatives (show)

anti-Fc Receptor (FcRn) antibody Primary Antibody

适用: 人, 小鼠 cELISA, ELISA, FACS, IF 宿主: 小鼠 Monoclonal DVN24 unconjugated

使用细节 (hide)

应用备注

• Flow cytometry: 1.2 μg/10^6 cells
• ELISA: 1:200 - 1:400
• CELISA: 1:200 - 1:400

For each application a titration should be performed to determine the optimal concentration.

限制

仅限研究用

贮存及处理 (hide)

缓冲液

phosphate buffered saline, pH 7.2

注意事项

avoid repeated freezing and thawing

储存条件

4 °C

引用 (hide)

Christianson, Sun, Akilesh, Pesavento, Proetzel, Roopenian: "Monoclonal antibodies directed against human FcRn and their applications." in: mAbs, Vol. 4, Issue 2, pp. 208-16, (2014) (PubMed).

目标详细情况 (hide)

抗原

Fc Receptor (FcRn)

背景

The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT

UniProt

P55899