Fc Receptor (FcRn) 抗体
适用: 人
cELISA, ELISA, FACS, IF
宿主: 小鼠
Monoclonal
ADM31
unconjugated
(1 reference)
-
- 抗原
- Fc Receptor (FcRn)
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- 非结合性
- 应用范围
- Cell-ELISA (cELISA), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)
- 产品特性
- based on recognition of the complete native protein expressed on transfected mammalian cells
- 纯化方法
- Purified, Protein A
- 免疫原
- Antibodies were generated by immunizing mouse FcRn-deficient mice with spleen cells from mice transgenic for human FcRn.
- 克隆位点
- ADM31
- 亚型
- IgG2b
-
anti-Fc Receptor (FcRn) antibody
适用: 人, 小鼠 cELISA, ELISA, FACS, IF 宿主: 小鼠 Monoclonal DVN24 unconjugated
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- 应用备注
-
- Flow cytometry: 1.2 μg/10^6 cells
- ELISA: 1:200 - 1:400
- CELISA: 1:200 - 1:400
- 限制
- 仅限研究用
-
- 缓冲液
- phosphate buffered saline, pH 7.2
- 注意事项
- avoid repeated freezing and thawing
- 储存条件
- 4 °C
-
-
: "Monoclonal antibodies directed against human FcRn and their applications." in: mAbs, Vol. 4, Issue 2, pp. 208-16, (2014) (PubMed).
-
: "Monoclonal antibodies directed against human FcRn and their applications." in: mAbs, Vol. 4, Issue 2, pp. 208-16, (2014) (PubMed).
-
- 抗原
- Fc Receptor (FcRn)
- 背景
-
The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT - UniProt
- P55899
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