DNA Damage Repair
DNA是合成任意生物的基因信息的载体。DNA中修复的基因编码对于亚细胞放大可见的过程和生物总体功能至关重要。尽管如此，DNA一直受到内来源的损伤，比如：水解、氧化、烷基化或复制错误。另外，电离辐射、紫外线辐射和过多的化学试剂已经成为威胁DNA完整性的外部因素。
与RNA和蛋白不一样的是，DNA受损后不能降解重新合成。而是存在多种修复途径来确保DNA仍然保持完好。在1974年，弗朗西斯·克里克注意到“在DNA修复中，我们完全漏掉了酶可能的作用。我后来意识到DNA很珍贵，因此有可能存在多种不同的机制。
到今天这个预言还是适用：参与到DNA修复途径复杂的网络中后，一百多个基因被表征。DNA损伤可以通过六种不同的途径修复，这取决于损伤的类型：化学改性、未合并的核苷酸，通过直接反转（DR）、错配修复（MMR）和核苷酸切除修复机制反转交联。DNA单链断裂通过基本切除修复改善。高诱变DNA双链断裂最后通过多种复杂的途径修复，这些途径依赖于姐妹染色单体（在细胞周期S或G2阶段）的同源重组（HR）或双链断裂两端的非同源末端接合（NHEJ）。在DNA损伤不能及时修复的情况下，专门的DNA聚合酶启动跨损伤合成（TLS），从而防止DNA复制叉停止。造成这些修复途径的组件不工作的突变会导致疾病，比如：着色性干皮病、共济失调毛细血管扩张、范科尼贫血和患癌症的倾向。
另外，对于目前通常利用细胞DNA修复机制的靶向基因组编辑方法来说，这些修复机制受到高度关注。
Download pathway image as PDF
Canonical Non-Homologous End-Joining
PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide):
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].
更多...
XRCC6 - X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 6
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions...
XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining)):
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or...
| ATM (Ataxia Telangiectasia Mutated): | ATM 抗体 | ATM ELISA试剂盒 | ATM 蛋白 |
| TRIM29 (Tripartite Motif Containing 29): | TRIM29 抗体 | TRIM29 蛋白 | |
| ATR (Ataxia Telangiectasia and Rad3 Related): | ATR 抗体 | ||
| H2AFX - H2A Histone Family, Member X: | H2AFX 抗体 | H2AFX ELISA试剂盒 | H2AFX 蛋白 |
| XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4): | XRCC4 抗体 | XRCC4 ELISA试剂盒 | XRCC4 蛋白 |
| LIG4 - Ligase IV, DNA, ATP-Dependent: | LIG4 抗体 | LIG4 ELISA试剂盒 | LIG4 蛋白 |
| NHEJ1 - Nonhomologous End-Joining Factor 1: | NHEJ1 抗体 | NHEJ1 ELISA试剂盒 | NHEJ1 蛋白 |
| APTX - Aprataxin: | APTX 抗体 | APTX ELISA试剂盒 | APTX 蛋白 |
| APLF (Aprataxin and PNKP Like Factor): | APLF 抗体 | APLF 蛋白 | |
| DCLRE1C (DNA Cross-Link Repair 1C): | DCLRE1C 抗体 | DCLRE1C 蛋白 | |
| PNKP (Polynucleotide Kinase 3'-Phosphatase): | PNKP 抗体 | PNKP ELISA试剂盒 | PNKP 蛋白 |
| DNTT - Deoxynucleotidyltransferase, terminal: | DNTT 抗体 | DNTT ELISA试剂盒 | DNTT 蛋白 |
| POLL (Polymerase (DNA Directed), lambda): | POLL 抗体 | POLL 蛋白 | |
| POLM - Polymerase (DNA Directed), mu: | POLM 抗体 | POLM 蛋白 | |
| MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): | MRE11A 抗体 | MRE11A ELISA试剂盒 | MRE11A 蛋白 |
| RAD50 (RAD50 Homolog (S. Cerevisiae)): | RAD50 抗体 | RAD50 ELISA试剂盒 | RAD50 蛋白 |
| NBN - Nibrin: | NBN 抗体 | NBN ELISA试剂盒 | NBN 蛋白 |
| TP53BP1 (Tumor Protein P53 Binding Protein 1): | TP53BP1 抗体 | TP53BP1 ELISA试剂盒 | TP53BP1 蛋白 |
Microhomology-Mediated End-Joining
PARP1 (Poly (ADP-Ribose) Polymerase 1):
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery...
更多...
| LIG3 (Ligase III, DNA, ATP-Dependent): | LIG3 抗体 | LIG3 ELISA试剂盒 | LIG3 蛋白 |
| LIG2 - Ligase II, DNA, ATP-Dependent: | |||
| PARP2 - Poly (ADP-Ribose) Polymerase 2: | PARP2 抗体 | PARP2 ELISA试剂盒 | PARP2 蛋白 |
| LIG1 (Ligase I, DNA, ATP-Dependent): | LIG1 抗体 | LIG1 ELISA试剂盒 | LIG1 蛋白 |
| ATM (Ataxia Telangiectasia Mutated): | ATM 抗体 | ATM ELISA试剂盒 | ATM 蛋白 |
| TRIM29 (Tripartite Motif Containing 29): | TRIM29 抗体 | TRIM29 蛋白 | |
| ATR (Ataxia Telangiectasia and Rad3 Related): | ATR 抗体 | ||
| RBBP8 - Retinoblastoma Binding Protein 8: | RBBP8 抗体 | RBBP8 蛋白 | |
| MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): | MRE11A 抗体 | MRE11A ELISA试剂盒 | MRE11A 蛋白 |
| RAD50 (RAD50 Homolog (S. Cerevisiae)): | RAD50 抗体 | RAD50 ELISA试剂盒 | RAD50 蛋白 |
| NBN - Nibrin: | NBN 抗体 | NBN ELISA试剂盒 | NBN 蛋白 |
| RECQL2 - RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding: | RECQL2 抗体 |
Homologous Recombination
RAD51 (DNA Repair Protein Homolog 1):
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of...
更多...
BRCA1 (Breast Cancer 1):
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded...
BRCA2 (Breast Cancer 2, Early Onset):
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are...
| POLE (Polymerase (DNA Directed), Epsilon, Catalytic Subunit): | POLE 抗体 | ||
| POLE2 - Polymerase (DNA Directed), epsilon 2 (p59 Subunit): | POLE2 抗体 | POLE2 蛋白 | |
| POLE3 - Polymerase (DNA Directed), epsilon 3 (p17 Subunit): | POLE3 抗体 | POLE3 蛋白 | |
| POLE4 (Polymerase (DNA-Directed), epsilon 4 (p12 Subunit)): | POLE4 抗体 | POLE4 蛋白 | |
| POLD1 - Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa: | POLD1 抗体 | POLD1 蛋白 | |
| POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit): | POLD2 抗体 | POLD2 蛋白 | |
| POLD3 - Polymerase (DNA-Directed), delta 3, Accessory Subunit: | POLD3 抗体 | POLD3 蛋白 | |
| POLD4 (Polymerase (DNA-Directed), delta 4, Accessory Subunit): | POLD4 抗体 | POLD4 蛋白 | |
| ATM (Ataxia Telangiectasia Mutated): | ATM 抗体 | ATM ELISA试剂盒 | ATM 蛋白 |
| TRIM29 (Tripartite Motif Containing 29): | TRIM29 抗体 | TRIM29 蛋白 | |
| ATR (Ataxia Telangiectasia and Rad3 Related): | ATR 抗体 | ||
| Rad51B - RAD51 Homolog B (S. Cerevisiae): | Rad51B 抗体 | Rad51B 蛋白 | |
| RAD51C (RAD51 Homolog C (S. Cerevisiae)): | RAD51C 抗体 | RAD51C 蛋白 | |
| XRCC2 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 2): | XRCC2 抗体 | XRCC2 ELISA试剂盒 | XRCC2 蛋白 |
| XRCC3 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3): | XRCC3 抗体 | XRCC3 蛋白 | |
| BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1): | BRIP1 抗体 | BRIP1 ELISA试剂盒 | |
| BARD1 (BRCA1 Associated RING Domain 1): | BARD1 抗体 | BARD1 ELISA试剂盒 | BARD1 蛋白 |
| RBBP8 - Retinoblastoma Binding Protein 8: | RBBP8 抗体 | RBBP8 蛋白 | |
| FAM175A - Family with Sequence Similarity 175, Member A: | FAM175A 抗体 | FAM175A 蛋白 | |
| UIMC1 - Ubiquitin Interaction Motif Containing 1: | UIMC1 抗体 | UIMC1 ELISA试剂盒 | UIMC1 蛋白 |
| MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): | MRE11A 抗体 | MRE11A ELISA试剂盒 | MRE11A 蛋白 |
| RAD50 (RAD50 Homolog (S. Cerevisiae)): | RAD50 抗体 | RAD50 ELISA试剂盒 | RAD50 蛋白 |
| NBN - Nibrin: | NBN 抗体 | NBN ELISA试剂盒 | NBN 蛋白 |
| TP53BP1 (Tumor Protein P53 Binding Protein 1): | TP53BP1 抗体 | TP53BP1 ELISA试剂盒 | TP53BP1 蛋白 |
| RPA1 - Replication Protein A1, 70kDa: | RPA1 抗体 | RPA1 ELISA试剂盒 | RPA1 蛋白 |
| RPA2 (Replication Protein A2, 32kDa): | RPA2 抗体 | RPA2 ELISA试剂盒 | RPA2 蛋白 |
| RPA3 (Replication Protein A3, 14kDa): | RPA3 抗体 | RPA3 蛋白 | |
| PALB2 (Partner and Localizer of BRCA2): | PALB2 抗体 | PALB2 蛋白 | |
| TOP3A (Topoisomerase (DNA) III alpha): | TOP3A 抗体 | TOP3A ELISA试剂盒 | |
| RMI1 (Homolog of Yeast RecQ-mediated Genome Instability 1): | RMI1 抗体 | RMI1 ELISA试剂盒 | RMI1 蛋白 |
| RMI2 (RMI2, RecQ Mediated Genome Instability 2, Homolog (S. Cerevisiae)): | RMI2 抗体 | RMI2 ELISA试剂盒 | RMI2 蛋白 |
| DNA2 (DNA Replication Helicase 2 Homolog (Yeast)): | DNA2 抗体 | ||
| RECQL2 - RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding: | RECQL2 抗体 | ||
| RAD54L (RAD54-Like (S. Cerevisiae)): | RAD54L 抗体 | RAD54L 蛋白 | |
| MUS81 (MUS81 Endonuclease Homolog (S. Cerevisiae)): | MUS81 抗体 | MUS81 蛋白 | |
| SLX1B - SLX1 Structure-Specific Endonuclease Subunit Homolog B (S. Cerevisiae): | SLX1B 抗体 | SLX1B 蛋白 | |
| BTBD12 - BTB (POZ) Domain Containing 12: | BTBD12 抗体 | ||
| GEN1 (Gen Endonuclease Homolog 1 (Drosophila)): | GEN1 抗体 | ||
Single Strand Annealing
(MSH2):
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E....
ERCC1 (Excision Repair Cross Complementing Polypeptide-1):
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced...
| MSH3 (MutS Homolog 3 (E. Coli)): | MSH3 抗体 | ||
| ERCC4 - Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 4: | ERCC4 抗体 | ERCC4 ELISA试剂盒 | ERCC4 蛋白 |
| ATM (Ataxia Telangiectasia Mutated): | ATM 抗体 | ATM ELISA试剂盒 | ATM 蛋白 |
| TRIM29 (Tripartite Motif Containing 29): | TRIM29 抗体 | TRIM29 蛋白 | |
| ATR (Ataxia Telangiectasia and Rad3 Related): | ATR 抗体 | ||
| MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): | MRE11A 抗体 | MRE11A ELISA试剂盒 | MRE11A 蛋白 |
| RAD50 (RAD50 Homolog (S. Cerevisiae)): | RAD50 抗体 | RAD50 ELISA试剂盒 | RAD50 蛋白 |
| NBN - Nibrin: | NBN 抗体 | NBN ELISA试剂盒 | NBN 蛋白 |
| RPA1 - Replication Protein A1, 70kDa: | RPA1 抗体 | RPA1 ELISA试剂盒 | RPA1 蛋白 |
| RPA2 (Replication Protein A2, 32kDa): | RPA2 抗体 | RPA2 ELISA试剂盒 | RPA2 蛋白 |
| RPA3 (Replication Protein A3, 14kDa): | RPA3 抗体 | RPA3 蛋白 | |
| RAD52 (RAD52 Homolog (S. Cerevisiae)): | RAD52 抗体 | RAD52 ELISA试剂盒 | RAD52 蛋白 |
Break-Induced Replication
MCM2 - Minichromosome Maintenance Complex Component 2
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of...
MCM7 - Minichromosome Maintenance Complex Component 7
| RAD51 (DNA Repair Protein Homolog 1): | RAD51 抗体 | RAD51 ELISA试剂盒 | RAD51 蛋白 |
| MRE11A - MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae): | MRE11A 抗体 | MRE11A ELISA试剂盒 | MRE11A 蛋白 |
| RAD50 (RAD50 Homolog (S. Cerevisiae)): | RAD50 抗体 | RAD50 ELISA试剂盒 | RAD50 蛋白 |
| NBN - Nibrin: | NBN 抗体 | NBN ELISA试剂盒 | NBN 蛋白 |
| RPA1 - Replication Protein A1, 70kDa: | RPA1 抗体 | RPA1 ELISA试剂盒 | RPA1 蛋白 |
| RPA2 (Replication Protein A2, 32kDa): | RPA2 抗体 | RPA2 ELISA试剂盒 | RPA2 蛋白 |
| RPA3 (Replication Protein A3, 14kDa): | RPA3 抗体 | RPA3 蛋白 | |
| MCM3 (Minichromosome Maintenance Complex Component 3): | MCM3 抗体 | MCM3 蛋白 | |
| MCM4 (Minichromosome Maintenance Deficient 4): | MCM4 抗体 | MCM4 ELISA试剂盒 | MCM4 蛋白 |
| MCM5 - Minichromosome Maintenance Complex Component 5: | MCM5 抗体 | MCM5 ELISA试剂盒 | MCM5 蛋白 |
| MCM6 - Minichromosome Maintenance Complex Component 6: | MCM6 抗体 | MCM6 ELISA试剂盒 | MCM6 蛋白 |
Base Excision Repair
OGG1 (8-Oxoguanine DNA Glycosylase):
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the...
更多...
UNG (Uracil-DNA Glycosylase):
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by...
APEX1 - APEX Nuclease (Multifunctional DNA Repair Enzyme) 1
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that...
| MPG - N-Methylpurine-DNA Glycosylase: | MPG 抗体 | MPG ELISA试剂盒 | MPG 蛋白 |
| SMUG1 - Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1: | SMUG1 抗体 | SMUG1 ELISA试剂盒 | SMUG1 蛋白 |
| TDG - Thymine-DNA Glycosylase: | TDG 抗体 | TDG ELISA试剂盒 | TDG 蛋白 |
| MBD4 (Methyl-CpG Binding Domain Protein 4): | MBD4 抗体 | MBD4 蛋白 | |
| MUTYH - MutY Homolog (E. Coli): | MUTYH 抗体 | MUTYH ELISA试剂盒 | MUTYH 蛋白 |
| NEIL1 (Endonuclease VIII-Like 1): | NEIL1 抗体 | NEIL1 ELISA试剂盒 | NEIL1 蛋白 |
| NEIL2 (Nei Endonuclease VIII-Like 2 (E. Coli)): | NEIL2 抗体 | NEIL2 蛋白 | |
| NEIL3 (Nei Endonuclease VIII-Like 3 (E. Coli)): | NEIL3 抗体 | NEIL3 ELISA试剂盒 | NEIL3 蛋白 |
| POLB (Polymerase (DNA Directed), beta): | POLB 抗体 | POLB ELISA试剂盒 | POLB 蛋白 |
| POLD1 - Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa: | POLD1 抗体 | POLD1 蛋白 | |
| POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit): | POLD2 抗体 | POLD2 蛋白 | |
| POLD3 - Polymerase (DNA-Directed), delta 3, Accessory Subunit: | POLD3 抗体 | POLD3 蛋白 | |
| POLD4 (Polymerase (DNA-Directed), delta 4, Accessory Subunit): | POLD4 抗体 | POLD4 蛋白 | |
| FEN1 (Flap Structure-Specific Endonuclease 1): | FEN1 抗体 | FEN1 ELISA试剂盒 | FEN1 蛋白 |
| LIG1 (Ligase I, DNA, ATP-Dependent): | LIG1 抗体 | LIG1 ELISA试剂盒 | LIG1 蛋白 |
Nuleotide Excision Repair
POLR2B - Polymerase (RNA) II (DNA Directed) Polypeptide B, 140kDa
This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA. [provided by RefSeq, Jul 2008].
更多...
XPC (Xeroderma Pigmentosum, Complementation Group C):
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including...
DDB1 (Damage Specific DNA Binding Protein 1):
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48)...
| XPA (Xeroderma Pigmentosum, Complementation Group A): | XPA 抗体 | XPA ELISA试剂盒 | XPA 蛋白 |
| RAD23A (RAD23 Homolog A (S. Cerevisiae)): | RAD23A 抗体 | RAD23A 蛋白 | |
| RAD23B - RAD23 Homolog B (S. Cerevisiae): | RAD23B 抗体 | RAD23B ELISA试剂盒 | RAD23B 蛋白 |
| CETN2 (Centrin, EF-Hand Protein, 2): | CETN2 抗体 | CETN2 蛋白 | |
| DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa): | DDB2 抗体 | DDB2 ELISA试剂盒 | DDB2 蛋白 |
| ERCC1 (Excision Repair Cross Complementing Polypeptide-1): | ERCC1 抗体 | ERCC1 ELISA试剂盒 | ERCC1 蛋白 |
| ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2): | ERCC2 抗体 | ERCC2 蛋白 | |
| ERCC3 - DNA Repair Protein Complementing XP-B Cells: | ERCC3 抗体 | ERCC3 蛋白 | |
| GTF2H1 - General Transcription Factor IIH, Polypeptide 1, 62kDa: | GTF2H1 抗体 | GTF2H1 ELISA试剂盒 | GTF2H1 蛋白 |
| GTF2H4 (General Transcription Factor IIH, Polypeptide 4, 52kDa): | GTF2H4 抗体 | GTF2H4 蛋白 | |
| GTF2H3 (General Transcription Factor IIH, Polypeptide 3, 34kD): | GTF2H3 抗体 | GTF2H3 蛋白 | |
| GTF2H5 - General Transcription Factor IIH, Polypeptide 5: | GTF2H5 抗体 | GTF2H5 蛋白 | |
| CDK7 (Cyclin-Dependent Kinase 7): | CDK7 抗体 | CDK7 ELISA试剂盒 | CDK7 蛋白 |
| RFC1 - Replication Factor C (Activator 1) 1, 145kDa: | RFC1 抗体 | RFC1 ELISA试剂盒 | RFC1 蛋白 |
| RFC2 (Replication Factor C (Activator 1) 2, 40kDa): | RFC2 抗体 | RFC2 蛋白 | |
| RFC3 - Replication Factor C (Activator 1) 3, 38kDa: | RFC3 抗体 | RFC3 蛋白 | |
| RFC4 (Replication Factor C (Activator 1) 4, 37kDa): | RFC4 抗体 | RFC4 蛋白 | |
| RFC5 (Replication Factor C (Activator 1) 5, 36.5kDa): | RFC5 抗体 | RFC5 蛋白 | |
| POLK - Polymerase (DNA Directed) kappa: | POLK 抗体 | POLK 蛋白 | |
| ERCC4 - Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 4: | ERCC4 抗体 | ERCC4 ELISA试剂盒 | ERCC4 蛋白 |
| ERCC5 - DNA Repair Protein Complementing XP-G Cells: | ERCC5 抗体 | ERCC5 ELISA试剂盒 | ERCC5 蛋白 |
| ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6): | ERCC6 抗体 | ERCC6 蛋白 | |
| ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8): | ERCC8 抗体 | ERCC8 蛋白 | |
| POLE (Polymerase (DNA Directed), Epsilon, Catalytic Subunit): | POLE 抗体 | ||
| POLE2 - Polymerase (DNA Directed), epsilon 2 (p59 Subunit): | POLE2 抗体 | POLE2 蛋白 | |
| POLE3 - Polymerase (DNA Directed), epsilon 3 (p17 Subunit): | POLE3 抗体 | POLE3 蛋白 | |
| POLE4 (Polymerase (DNA-Directed), epsilon 4 (p12 Subunit)): | POLE4 抗体 | POLE4 蛋白 | |
| PCNA (Proliferating Cell Nuclear Antigen): | PCNA 抗体 | PCNA ELISA试剂盒 | PCNA 蛋白 |
| XRCC1 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1): | XRCC1 抗体 | XRCC1 ELISA试剂盒 | XRCC1 蛋白 |
| FEN1 (Flap Structure-Specific Endonuclease 1): | FEN1 抗体 | FEN1 ELISA试剂盒 | FEN1 蛋白 |
| LIG1 (Ligase I, DNA, ATP-Dependent): | LIG1 抗体 | LIG1 ELISA试剂盒 | LIG1 蛋白 |
| RPA1 - Replication Protein A1, 70kDa: | RPA1 抗体 | RPA1 ELISA试剂盒 | RPA1 蛋白 |
| RPA2 (Replication Protein A2, 32kDa): | RPA2 抗体 | RPA2 ELISA试剂盒 | RPA2 蛋白 |
| RPA3 (Replication Protein A3, 14kDa): | RPA3 抗体 | RPA3 蛋白 | |
Mismatch Repair
(MSH2):
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
更多...
MSH3 (MutS Homolog 3 (E. Coli)):
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS...
MSH6 (MutS Homolog 6 (E. Coli)):
| MLH1 (MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli)): | MLH1 抗体 | MLH1 ELISA试剂盒 | MLH1 蛋白 |
| PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae)): | PMS2 抗体 | PMS2 蛋白 | |
| RFC1 - Replication Factor C (Activator 1) 1, 145kDa: | RFC1 抗体 | RFC1 ELISA试剂盒 | RFC1 蛋白 |
| RFC2 (Replication Factor C (Activator 1) 2, 40kDa): | RFC2 抗体 | RFC2 蛋白 | |
| RFC3 - Replication Factor C (Activator 1) 3, 38kDa: | RFC3 抗体 | RFC3 蛋白 | |
| RFC4 (Replication Factor C (Activator 1) 4, 37kDa): | RFC4 抗体 | RFC4 蛋白 | |
| RFC5 (Replication Factor C (Activator 1) 5, 36.5kDa): | RFC5 抗体 | RFC5 蛋白 | |
| POLD1 - Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa: | POLD1 抗体 | POLD1 蛋白 | |
| POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit): | POLD2 抗体 | POLD2 蛋白 | |
| POLD3 - Polymerase (DNA-Directed), delta 3, Accessory Subunit: | POLD3 抗体 | POLD3 蛋白 | |
| PCNA (Proliferating Cell Nuclear Antigen): | PCNA 抗体 | PCNA ELISA试剂盒 | PCNA 蛋白 |
| LIG1 (Ligase I, DNA, ATP-Dependent): | LIG1 抗体 | LIG1 ELISA试剂盒 | LIG1 蛋白 |
| RPA1 - Replication Protein A1, 70kDa: | RPA1 抗体 | RPA1 ELISA试剂盒 | RPA1 蛋白 |
| RPA2 (Replication Protein A2, 32kDa): | RPA2 抗体 | RPA2 ELISA试剂盒 | RPA2 蛋白 |
| RPA3 (Replication Protein A3, 14kDa): | RPA3 抗体 | RPA3 蛋白 | |
| EXO1 - Exonuclease 1: | EXO1 抗体 | EXO1 蛋白 |
Direct Reversal
MGMT (O6-Methylguanine-DNA-Methyltransferase):
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a
更多...
ALKBH - AlkB, Alkylation Repair Homolog 1 (E. Coli)
ALKBH2 - AlkB, Alkylation Repair Homolog 2
| ALKBH3 - AlkB, Alkylation Repair Homolog 3 (E. Coli): | ALKBH3 抗体 | ALKBH3 ELISA试剂盒 | ALKBH3 蛋白 |
