This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. [provided by RefSeq, Jul 2008].
Masuda, Takahashi, Tsunekuni, Minami, Sumii, Miyagawa, Kamiya: "Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domain." in: The Journal of biological chemistry, Vol. 276, Issue 18, pp. 15051-8, (2001) (PubMed).
Aliases for REV1 抗体
DNA-directed DNA polymerase (REV1) 抗体 HIG1 hypoxia inducible domain family member 1C (HIGD1C) 抗体 REV1, DNA directed polymerase (Rev1) 抗体 REV1, DNA directed polymerase (REV1) 抗体 1110027I23Rik 抗体 ARABIDOPSIS THALIANA HOMOLOG OF REVERSIONLESS 1 抗体 ATREV1 抗体 AU022044 抗体 K23L20.9 抗体 K23L20_9 抗体 Rev1l 抗体 REV1L 抗体