DDB1 抗体
(Damage Specific DNA Binding Protein 1 (DDB1))
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| DDB1 抗体 (C-Term) | 人 | 兔 Polyclonal |
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| DDB1 抗体 (C-Term) | 人, 小鼠 | 山羊 Polyclonal |
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| DDB1 抗体 | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| DDB1 抗体 (C-Term) | 人 | 兔 Polyclonal |
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| DDB1 抗体 | 人 | 兔 Monoclonal |
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| DDB1 抗体 (AA 1044-1140) | 人 | 小鼠 Monoclonal |
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| DDB1 抗体 (AA 1011-1140) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| DDB1 抗体 | 人 | 小鼠 Monoclonal |
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| Recombinant DDB1 抗体 | 人 | 兔 Monoclonal |
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| DDB1 抗体 (C-Term) | 人, 小鼠 | 兔 Polyclonal |
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| DDB1 抗体 (C-Term) | 人, 小鼠 | 兔 Polyclonal |
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| DDB1 抗体 (C-Term) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| DDB1 抗体 (AA 741-943) | 人 | 兔 Polyclonal |
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| DDB1 抗体 (AA 1044-1140) | 人 | 小鼠 Polyclonal |
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| DDB1 抗体 (AA 1-1140) | 人 | 小鼠 Polyclonal |
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| DDB1 抗体 (AA 951-1140) | 人 | 兔 Polyclonal |
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| DDB1 抗体 (C-Term) | 人 | 兔 Polyclonal |
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| DDB1 抗体 | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| DDB1 抗体 | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| DDB1 抗体 (C-Term) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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Primary Antibody
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- ICC (Immunocytochemistry: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
1 reference
KO 验证
- 质量等级
- KO Validated
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- ELISA (ELISA: 所列应用)
- 质量等级
- Verified
- 适用
- 人, 小鼠
- 宿主
- 山羊
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- IF (Immunofluorescence: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- IP (Immunoprecipitation: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- ELISA (ELISA: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- WB (Western Blotting: 有验证图片)
- ISt (Immunostaining: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 4C5
- 标记
- unconjugated
- 抗体亚型
- IgG2a
- 抗原表位
- AA 1044-1140
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- FACS (Flow Cytometry: 有验证图片)
- IF (Immunofluorescence: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
- IHC (fro) (Immunohistochemistry (Frozen Sections): 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 1011-1140
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IP (Immunoprecipitation: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 标记
- unconjugated
- 抗体亚型
- IgG1 kappa
Primary Antibody
- WB (Western Blotting: 有验证图片)
- FACS (Flow Cytometry: 有验证图片)
- 质量等级
- KD Validated
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Monoclonal
- 克隆
- 23GB2265
- 标记
- unconjugated
- 蛋白类型
- Recombinant Antibody
- 抗体亚型
- IgG
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- IP (Immunoprecipitation: 所列应用)
- IHC (fp) (Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections): 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
- IHC (Immunohistochemistry: 所列应用)
- IF (Immunofluorescence: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 741-943
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 1044-1140
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 1-1140
Primary Antibody
- ELISA (ELISA: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- IHC (fro) (Immunohistochemistry (Frozen Sections): 所列应用)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 951-1140
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- WB (Western Blotting: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Latest Publications for our DDB1 抗体
: "Comparative Interactome Analysis of Emerin, MAN1 and LEM2 Reveals a Unique Role for LEM2 in Nucleotide Excision Repair." in: Cells, Vol. 9, Issue 2, (2020) (PubMed).
: "Quantitative proteomic analysis revealed changes in protein synthesis and mitochondrial functions after acute DNA damage in mouse neural stem cells." in: Neuroscience letters, Vol. 653, pp. 355-361, (2018) (PubMed).
: "The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity." in: Oncogene, Vol. 32, Issue 39, pp. 4721-6, (2013) (PubMed).
: "A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery." in: Nature structural & molecular biology, Vol. 17, Issue 1, pp. 105-11, (2010) (PubMed).
: "DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress." in: Cancer research, Vol. 69, Issue 6, pp. 2630-7, (2009) (PubMed).
: "A genetic screen for candidate tumor suppressors identifies REST." in: Cell, Vol. 121, Issue 6, pp. 837-48, (2005) (PubMed).
: "Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation." in: Nucleic acids research, Vol. 30, Issue 11, pp. 2588-98, (2002) (PubMed).
: "Identification of rat DDB1, a putative DNA repair protein, and functional correlation with its damaged-DNA recognition activity." in: Journal of biomedical science, Vol. 9, Issue 4, pp. 371-80, (2002) (PubMed).
: "Cullin 4A associates with the UV-damaged DNA-binding protein DDB." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35309-12, (2000) (PubMed).
: "Characterization of DNA recognition by the human UV-damaged DNA-binding protein." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 20027-33, (1999) (PubMed).
: "Quantitative proteomic analysis revealed changes in protein synthesis and mitochondrial functions after acute DNA damage in mouse neural stem cells." in: Neuroscience letters, Vol. 653, pp. 355-361, (2018) (PubMed).
: "The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity." in: Oncogene, Vol. 32, Issue 39, pp. 4721-6, (2013) (PubMed).
: "A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery." in: Nature structural & molecular biology, Vol. 17, Issue 1, pp. 105-11, (2010) (PubMed).
: "DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress." in: Cancer research, Vol. 69, Issue 6, pp. 2630-7, (2009) (PubMed).
: "A genetic screen for candidate tumor suppressors identifies REST." in: Cell, Vol. 121, Issue 6, pp. 837-48, (2005) (PubMed).
: "Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation." in: Nucleic acids research, Vol. 30, Issue 11, pp. 2588-98, (2002) (PubMed).
: "Identification of rat DDB1, a putative DNA repair protein, and functional correlation with its damaged-DNA recognition activity." in: Journal of biomedical science, Vol. 9, Issue 4, pp. 371-80, (2002) (PubMed).
: "Cullin 4A associates with the UV-damaged DNA-binding protein DDB." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35309-12, (2000) (PubMed).
: "Characterization of DNA recognition by the human UV-damaged DNA-binding protein." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 20027-33, (1999) (PubMed).
Aliases for DDB1 抗体
damage specific DNA binding protein 1 (DDB1) 抗体damage-specific DNA binding protein 1, 127kDa (ddb1) 抗体
DNA damage-binding protein 1 (LOC100187356) 抗体
damage specific DNA binding protein 1 (Ddb1) 抗体
damage-specific DNA binding protein 1 (Ddb1) 抗体
DNA damage-binding protein 1 (ddb-1) 抗体
127kDa 抗体
AA408517 抗体
DDB1 抗体
ddb1 抗体
DDBA 抗体
ddba 抗体
p127-Ddb1 抗体
UV-DDB1 抗体
uv-ddb1 抗体
XAP1 抗体
xap1 抗体
XPCE 抗体
xpce 抗体
XPE 抗体
xpe 抗体
XPE-BF 抗体
xpe-bf 抗体
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