DDB1 产品
(Damage Specific DNA Binding Protein 1 (DDB1))
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The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012].
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Featured DDB1 Categories
DDB1 抗体
High quality antibodies with extensive validation data.
DDB1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
DDB1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DDB1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (1)
- (6)
Cat. No.
ABIN184570
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), ICC
Validations
- (1)
- (8)
Cat. No.
ABIN2854664
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (5)
Cat. No.
ABIN7260707
Quantity
200 μL
Datasheet
Datasheet
Recommended DDB1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1129984
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1129985
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1129986
Quantity
96 tests
Datasheet
Datasheet
Recommended DDB1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351255
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1351257
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3092112
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our DDB1 Products
: "Comparative Interactome Analysis of Emerin, MAN1 and LEM2 Reveals a Unique Role for LEM2 in Nucleotide Excision Repair." in: Cells, Vol. 9, Issue 2, (2020) (PubMed).: "Quantitative proteomic analysis revealed changes in protein synthesis and mitochondrial functions after acute DNA damage in mouse neural stem cells." in: Neuroscience letters, Vol. 653, pp. 355-361, (2018) (PubMed).
: "The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity." in: Oncogene, Vol. 32, Issue 39, pp. 4721-6, (2013) (PubMed).
: "A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery." in: Nature structural & molecular biology, Vol. 17, Issue 1, pp. 105-11, (2010) (PubMed).
: "DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress." in: Cancer research, Vol. 69, Issue 6, pp. 2630-7, (2009) (PubMed).
: "A genetic screen for candidate tumor suppressors identifies REST." in: Cell, Vol. 121, Issue 6, pp. 837-48, (2005) (PubMed).
: "Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation." in: Nucleic acids research, Vol. 30, Issue 11, pp. 2588-98, (2002) (PubMed).
: "Identification of rat DDB1, a putative DNA repair protein, and functional correlation with its damaged-DNA recognition activity." in: Journal of biomedical science, Vol. 9, Issue 4, pp. 371-80, (2002) (PubMed).
: "Cullin 4A associates with the UV-damaged DNA-binding protein DDB." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35309-12, (2000) (PubMed).
: "Characterization of DNA recognition by the human UV-damaged DNA-binding protein." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 20027-33, (1999) (PubMed).
Synonyms and alternative names related to DDB1
damage specific DNA binding protein 1 (DDB1), damage-specific DNA binding protein 1, 127kDa (ddb1), DNA damage-binding protein 1 (LOC100187356), damage specific DNA binding protein 1 (Ddb1), damage-specific DNA binding protein 1 (Ddb1), DNA damage-binding protein 1 (ddb-1), 127kDa, AA408517, DDB1, ddb1, DDBA, ddba, p127-Ddb1, UV-DDB1, uv-ddb1, XAP1, xap1, XPCE, xpce, XPE, xpe, XPE-BF, xpe-bfProtein level used designations for DDB1
- DDB p127 subunit
- DNA damage-binding protein 1
- DNA damage-binding protein a
- HBV X-associated protein 1
- UV-DDB 1
- UV-damaged DNA-binding factor
- UV-damaged DNA-binding protein 1
- XAP-1
- XPE-binding factor
- xeroderma pigmentosum group E-complementing protein
- damage-specific DNA-binding protein 1
- damage-specific DNA binding protein 1, 127kDa
- DNA damage-binding protein 1-like
- DNA repair protein
- damage-specific DNA-binding protein, DNA repair
- damaged-DNA recognition protein 1
- damage specific DNA binding protein 1
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