p53 Protein (AA 2-393) (His-SUMO Tag)
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- 抗原 See all p53 (TP53) 蛋白
- p53 (TP53) (Tumor Protein P53 (TP53))
- 蛋白类型
- Recombinant
- 产品特性
- AA 2-393
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This p53 protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- EEPQSDPSVE PPLSQETFSD LWKLLPENNV LSPLPSQAMD DLMLSPDDIE QWFTEDPGPD EAPRMPEAAP PVAPAPAAPT PAAPAPAPSW PLSSSVPSQK TYQGSYGFRL GFLHSGTAKS VTCTYSPALN KMFCQLAKTC PVQLWVDSTP PPGTRVRAMA IYKQSQHMTE VVRRCPHHER CSDSDGLAPP QHLIRVEGNL RVEYLDDRNT FRHSVVVPYE PPEVGSDCTT IHYNYMCNSS CMGGMNRRPI LTIITLEDSS GNLLGRNSFE VRVCACPGRD RRTEEENLRK KGEPHHELPP GSTKRALPNN TSSSPQPKKK PLDGEYFTLQ IRGRERFEMF RELNEALELK DAQAGKEPGG SRAHSSHLKS KKGQSTSRHK KLMFKTEGPD SD
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product TP53 蛋白
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Tumor Protein P53 (TP53) (AA 1-393) protein (GST tag)
TP53 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Tumor Protein P53 (TP53) (Active) protein (His tag)TP53 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant STD, PI, in vitro Active
Tumor Protein P53 (TP53) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)TP53 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining STD, AbP
Tumor Protein P53 (TP53) (AA 1-391) protein (His tag)TP53 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Tumor Protein P53 (TP53) (AA 94-201) protein (GST tag)TP53 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Tumor Protein P53 (TP53) protein (His-SUMO Tag)TP53 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90% as determined by SDS-PAGE. ELISA
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- p53 (TP53) (Tumor Protein P53 (TP53))
- 别名
- P53 (TP53 产品)
- 别名
- BCC7 Protein, LFS1 Protein, P53 Protein, TRP53 Protein, p53 Protein, Trp53 Protein, brp53 Protein, drp53 Protein, etID22686.5 Protein, fb40d06 Protein, wu:fb40d06 Protein, zgc:111919 Protein, Tp53 Protein, bbl Protein, bfy Protein, bhy Protein, p44 Protein, tp53 Protein, Xp53 Protein, TP53 Protein, tumor protein p53 Protein, cellular tumor antigen p53 Protein, transformation related protein 53 Protein, tumor protein p53 L homeolog Protein, TP53 Protein, CpipJ_CPIJ002758 Protein, Tp53 Protein, tp53 Protein, Trp53 Protein, tp53.L Protein
- 背景
- Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction ses to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and se to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 .
- 分子量
- 59.49 kDa
- UniProt
- P04637
- 途径
- p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect
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