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p53 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

TP53 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining STD, AbP
产品编号 ABIN2734068
发货至: 中国
  • 抗原 See all p53 (TP53) 蛋白
    p53 (TP53) (Tumor Protein P53 (TP53))
    蛋白类型
    Recombinant
    产品特性
    Transcript Variant 1
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    资源
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    HEK-293 Cells
    标记
    This p53 protein is labelled with Myc-DYKDDDDK Tag.
    应用范围
    Standard (STD), Antibody Production (AbP)
    产品特性
    • Recombinant human TP53 / p53 (transcript variant 1) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    纯度
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product TP53 蛋白
  • 应用备注
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    说明

    The tag is located at the C-terminal.

    限制
    仅限研究用
  • 浓度
    50 μg/mL
    缓冲液
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    储存条件
    -80 °C
    储存方法
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Li, Xia, Su, Qin, Chen, Li, Dong, Ding, Li, Huang, Ge, Hou, Wang, Sun, Bai, Shen, Fang, Liu, Zhang, Zhang, Zhang, Shao: "Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse." in: Scientific reports, Vol. 6, pp. 26187, (2016) (PubMed).

    Lebedev, Nemajerova, Foda, Kornaj, Tong, Moll, Seeliger: "A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems." in: Journal of molecular biology, Vol. 428, Issue 20, pp. 4154-4167, (2016) (PubMed).

  • 抗原
    p53 (TP53) (Tumor Protein P53 (TP53))
    别名
    Tp53,p53 (TP53 产品)
    别名
    BCC7 Protein, LFS1 Protein, P53 Protein, TRP53 Protein, p53 Protein, Trp53 Protein, brp53 Protein, drp53 Protein, etID22686.5 Protein, fb40d06 Protein, wu:fb40d06 Protein, zgc:111919 Protein, Tp53 Protein, bbl Protein, bfy Protein, bhy Protein, p44 Protein, tp53 Protein, Xp53 Protein, TP53 Protein, tumor protein p53 Protein, cellular tumor antigen p53 Protein, transformation related protein 53 Protein, tumor protein p53 L homeolog Protein, TP53 Protein, CpipJ_CPIJ002758 Protein, Tp53 Protein, tp53 Protein, Trp53 Protein, tp53.L Protein
    背景
    This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
    分子量
    43.5 kDa
    NCBI登录号
    NP_000537
    途径
    p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect
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