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p53 Pathway

p53是最重要的肿瘤抑制基因之一，常被称为“基因组守护者”。在几乎所有的癌症中，都存在 p53基因或其调控回路中的一部分发生基因突变，由此可见其重要性。它通过防止由细胞应激或DNA损伤导致突变来保护基因组的稳定性。 p53通过调节细胞凋亡、抑制细胞周期进程、细胞分化、细胞生长阻滞及加速DNA修复来维持基因组的稳定。 p53是在哺乳动物细胞中保持低水平的特异性DNA结合转录因子， p53具有非常短的半衰期，因而在非应激细胞内几乎检测不到。这主要是在其抑制因子MDM2作用下，通过p53持续的泛素化和后期通过26S蛋白酶体降解实现。DNA损伤等细胞应激信号会抑制p53的泛素化，并导致其稳定和活化。一旦p53活化，将会与其下游目标的调控元件结合并调控其转录。从而可以启动基于p53的不同肿瘤抑制功能的多种细胞治疗方案。

血管生成

BAI1 (Brain-Specific Angiogenesis Inhibitor 1):

SERPINE1 (serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1):

CD82 (CD82):

PRSS55 (Protease, Serine, 55):

SERPINB5 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5):

细胞凋亡

APAF1 (Apoptotic Peptidase Activating Factor 1):

PIDD (P53-Induced Death Domain Protein):

BBC3 (BCL2 Binding Component 3):

BAX (BCL2-Associated X Protein):

FAS (Fas (TNF Receptor Superfamily, Member 6)):

MRPL41 (Mitochondrial Ribosomal Protein L41):

PMAIP1 - NOXA:

PDCD6IP - ALIX:

TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b):

TP53I3 (Tumor Protein P53 Inducible Protein 3):

核心调整

NRAS - GTPase NRas:

TP53 - p53:

MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse)):

DNA修复

RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible)):

XPC (Xeroderma Pigmentosum, Complementation Group C):

CRLF3 (Cytokine Receptor-Like Factor 3):

反应器

PRDX1 - Peroxiredoxin 1:

PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B):

EP300 - p300:

KAT2B (K(lysine) Acetyltransferase 2B):

PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1):

TANK (TRAF Family Member-Associated NFKB Activator):

生长抑制

CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1)):

GADD45A (Growth Arrest and DNA-Damage-Inducible, alpha):

SFN - Stratifin:

间介器

ATM (Ataxia Telangiectasia Mutated):

HMGB1 (High Mobility Group Box 1):

ARFGAP1 (ADP-Ribosylation Factor GTPase Activating Protein 1):

ATR (Ataxia Telangiectasia and Rad3 Related):

ATR 抗体

CHEK1 (Checkpoint Kinase 1):

CHEK2 (Checkpoint Kinase 2):

NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1):

PML (Promyelocytic Leukemia):

SCYL1 (SCY1-Like 1 (S. Cerevisiae)):

TRIM29 (Tripartite Motif Containing 29):

致癌基因激活

HRAS (HRas proto-oncogene, GTPase):

MYC - C-MYC:

DMP1 (Dentin Matrix Acidic phosphoprotein 1):

E2F1 (E2F Transcription Factor 1):

NRAS - GTPase NRas:

TBX2 (T-Box 2):

TWIST1 (Twist Homolog 1 (Drosophila)):

其他

CCNG1 - Cyclin G1:

MAP4 (Microtubule-Associated Protein 4):

PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D):

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血管生成

BAI1 (Brain-Specific Angiogenesis Inhibitor 1):

SERPINE1 (serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1):

CD82 (CD82):

PRSS55 (Protease, Serine, 55):

SERPINB5 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5):

细胞凋亡

APAF1 (Apoptotic Peptidase Activating Factor 1):

PIDD (P53-Induced Death Domain Protein):

BBC3 (BCL2 Binding Component 3):

BAX (BCL2-Associated X Protein):

FAS (Fas (TNF Receptor Superfamily, Member 6)):

MRPL41 (Mitochondrial Ribosomal Protein L41):

PMAIP1 - NOXA:

PDCD6IP - ALIX:

TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b):

TP53I3 (Tumor Protein P53 Inducible Protein 3):

核心调整

NRAS - GTPase NRas:

TP53 - p53:

MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse)):

DNA修复

RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible)):

XPC (Xeroderma Pigmentosum, Complementation Group C):

CRLF3 (Cytokine Receptor-Like Factor 3):

反应器

PRDX1 - Peroxiredoxin 1:

PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B):

EP300 - p300:

KAT2B (K(lysine) Acetyltransferase 2B):

PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1):

TANK (TRAF Family Member-Associated NFKB Activator):

生长抑制

CDKN1A (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1)):

GADD45A (Growth Arrest and DNA-Damage-Inducible, alpha):

SFN - Stratifin:

间介器

ATM (Ataxia Telangiectasia Mutated):

HMGB1 (High Mobility Group Box 1):

ARFGAP1 (ADP-Ribosylation Factor GTPase Activating Protein 1):

ATR (Ataxia Telangiectasia and Rad3 Related):

CHEK1 (Checkpoint Kinase 1):

CHEK2 (Checkpoint Kinase 2):

NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1):

PML (Promyelocytic Leukemia):

SCYL1 (SCY1-Like 1 (S. Cerevisiae)):

TRIM29 (Tripartite Motif Containing 29):

致癌基因激活

HRAS (HRas proto-oncogene, GTPase):

MYC - C-MYC:

DMP1 (Dentin Matrix Acidic phosphoprotein 1):

E2F1 (E2F Transcription Factor 1):

NRAS - GTPase NRas:

TBX2 (T-Box 2):

TWIST1 (Twist Homolog 1 (Drosophila)):

其他

CCNG1 - Cyclin G1:

MAP4 (Microtubule-Associated Protein 4):

PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D):

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