p53 蛋白
(Tumor Protein P53 (TP53))
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| p53 Protein (AA 1-393) (GST tag) | 人 | 小麦胚 |
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| p53 Protein (AA 1-391) (His tag) | 大鼠 | 大肠杆菌（E. Coli） |
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| p53 Protein (AA 1-393, full length) (His tag) | 人 | Mammalian Cells |
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| p53 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) | 人 | HEK-293 Cells |
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| p53 Protein (AA 1-393) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| p53 Protein (AA 1-393) (Strep Tag) | 人 | Cell-free protein synthesis (CFPS) |
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| p53 Protein (AA 25-305, Tetramer) (His-Avi Tag,PE,p53) | 人 | HEK-293 Cells |
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| p53 Protein (AA 1-393, R273C) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| p53 Protein (AA 7-393) (His-GFP tag Tag) | 人 | 大肠杆菌（E. Coli） |
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| p53 Protein (AA 7-393) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| p53 Protein (GST tag) | 人 | Baculovirus infected Insect Cells |
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| p53 Protein (GST tag) | 人 | 大肠杆菌（E. Coli） |
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| p53 蛋白 | 人 | 大肠杆菌（E. Coli） |
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| p53 Protein (AA 108-370) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| p53 Protein (AA 1-393) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| p53 Protein (AA 90-354) (His tag) | 大鼠 | 大肠杆菌（E. Coli） |
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| p53 Protein (AA 1-390) (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| p53 Protein (AA 133-393) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| p53 Protein (AA 134-387) (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| p53 Protein (AA 1-386) (His tag) | Cow | 大肠杆菌（E. Coli） |
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Protein
- AP (Affinity Purification: 所列应用)
- AA (Antibody Array: 所列应用)
- ELISA (ELISA: 所列应用)
- WB (Western Blotting: 所列应用)
3 references - 宿主
- 人
- 宿主
- 小麦胚
- 蛋白类型
- Recombinant
Protein
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 宿主
- 大鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- SDS (SDS-PAGE: 有验证图片)
- 宿主
- 人
- 宿主
- Mammalian Cells
- 蛋白类型
- Recombinant
- 纯度
- Greater than 85 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: 有验证图片)
- AcA (Activity Assay: 有验证图片)
- AbP (Antibody Production: 所列应用)
- STD (Standard: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 质量等级
- custom-made
- 宿主
- 人
- 宿主
- Cell-free protein synthesis (CFPS)
- 蛋白类型
- Recombinant
- 纯度
- approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
Protein
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 生物活性
- Active
Protein
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 80 %
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 大鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 97 %
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 80 %
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 97 %
Protein
- Imm (Immunogen: 所列应用)
- 宿主
- Cow
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Latest Publications for our p53 蛋白
: "The implication of autoantibodies in early diagnosis and monitoring of plasmonic photothermal therapy in the treatment of feline mammary carcinoma." in: Scientific reports, Vol. 11, Issue 1, pp. 10441, (2021) (PubMed).
: "Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse." in: Scientific reports, Vol. 6, pp. 26187, (2016) (PubMed).
: "A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems." in: Journal of molecular biology, Vol. 428, Issue 20, pp. 4154-4167, (2016) (PubMed).
: "LC-MS/MS-based targeted proteomics quantitatively detects the interaction between p53 and MDM2 in breast cancer." in: Journal of proteomics, Vol. 152, pp. 172-180, (2016) (PubMed).
: "A multiparametric serum marker panel as a complementary test to mammography for the diagnosis of node-negative early-stage breast cancer and DCIS in young women." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 23, Issue 9, pp. 1834-42, (2014) (PubMed).
: "Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance." in: Cell cycle (Georgetown, Tex.), Vol. 11, Issue 12, pp. 2367-79, (2012) (PubMed).
: "Characterization of the human p53 gene." in: Molecular and cellular biology, Vol. 6, Issue 5, pp. 1379-85, (1987) (PubMed).
: "Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells." in: The EMBO journal, Vol. 4, Issue 5, pp. 1251-5, (1985) (PubMed).
: "Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53." in: Molecular and cellular biology, Vol. 5, Issue 7, pp. 1601-10, (1985) (PubMed).
: "Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse." in: Scientific reports, Vol. 6, pp. 26187, (2016) (PubMed).
: "A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems." in: Journal of molecular biology, Vol. 428, Issue 20, pp. 4154-4167, (2016) (PubMed).
: "LC-MS/MS-based targeted proteomics quantitatively detects the interaction between p53 and MDM2 in breast cancer." in: Journal of proteomics, Vol. 152, pp. 172-180, (2016) (PubMed).
: "A multiparametric serum marker panel as a complementary test to mammography for the diagnosis of node-negative early-stage breast cancer and DCIS in young women." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 23, Issue 9, pp. 1834-42, (2014) (PubMed).
: "Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance." in: Cell cycle (Georgetown, Tex.), Vol. 11, Issue 12, pp. 2367-79, (2012) (PubMed).
: "Characterization of the human p53 gene." in: Molecular and cellular biology, Vol. 6, Issue 5, pp. 1379-85, (1987) (PubMed).
: "Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells." in: The EMBO journal, Vol. 4, Issue 5, pp. 1251-5, (1985) (PubMed).
: "Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53." in: Molecular and cellular biology, Vol. 5, Issue 7, pp. 1601-10, (1985) (PubMed).
Aliases for p53 蛋白
tumor protein p53 (TP53) 蛋白cellular tumor antigen p53 (CpipJ_CPIJ002758) 蛋白
tumor protein p53 (Tp53) 蛋白
tumor protein p53 (tp53) 蛋白
transformation related protein 53 (Trp53) 蛋白
tumor protein p53 L homeolog (tp53.L) 蛋白
bbl 蛋白
BCC7 蛋白
bfy 蛋白
bhy 蛋白
brp53 蛋白
drp53 蛋白
etID22686.5 蛋白
fb40d06 蛋白
LFS1 蛋白
p44 蛋白
P53 蛋白
p53 蛋白
Tp53 蛋白
tp53 蛋白
TP53 蛋白
TRP53 蛋白
Trp53 蛋白
wu:fb40d06 蛋白
Xp53 蛋白
zgc:111919 蛋白
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