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抗Mouse (Murine) GRB2 抗体:
抗Rat (Rattus) GRB2 抗体:
抗Human GRB2 抗体:
Human Polyclonal GRB2 Primary Antibody for IHC (p), WB - ABIN390236
Kondo, Hirayama, Sugito, Shono, Tanaka, Kitamura: Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation. in The Journal of biological chemistry 2008
Show all 3 Pubmed References
Human Polyclonal GRB2 Primary Antibody for ELISA, IHC - ABIN257708
Lowenstein, Daly, Batzer, Li, Margolis, Lammers, Ullrich, Skolnik, Bar-Sagi, Schlessinger: The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. in Cell 1992
Study shows that growth factor receptor binding protein (显示 GRAP2 抗体) 2 carboxyl-terminal SH3 domain (显示 ITSN1 抗体) can bivalently associate with two ligands, in an SH3 dependent manner. Extrapolating the results of this study to the in vivo conditions, Grb2 should bind the SLP65 (显示 BLNK 抗体) transducer module first, and then Vav (显示 VAV1 抗体) should associate.
Our findings position Grb2 as a key adaptor that integrates various cytokines response in cycling Hematopoietic Stem and Progenitor Cell .
Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 (显示 VAV1 抗体) activity and Grb2 stability
Myogenic differentiation depends on the expression regulation patterns of Grb2 and N-WASP.
Two Dtna (显示 DTNA 抗体) interactors, alpha-catulin (显示 CTNNAL1 抗体) (phosphorylation independent) and Grb2 (phosphorylation dependent) are localized to neuromuscular junctions in vivo, and are required for proper organization of neurotransmitter receptors on myotubes.
Grb2-deficient T cells show defects in T cell development, increased Th1 (显示 HAND1 抗体) and Th17 cell differentiation capacities, and impaired proliferation after activation by dendritic cells, which likely reduce the clinical symptoms of EAE.
provide evidence that CD28 (显示 CD28 抗体) and the TCR complex regulate NF-kappaB (显示 NFKB1 抗体) via different signaling modules of GRB-2/VAV1 (显示 VAV1 抗体) and LAT (显示 LAT 抗体)/ADAP (显示 APP 抗体) pathways respectively.
GRB2 physically links cyt (显示 CYGB 抗体)-PTPe (显示 PTPRE 抗体) with Src (显示 SRC 抗体) and enables cyt (显示 CYGB 抗体)-PTPe (显示 PTPRE 抗体) to activate Src (显示 SRC 抗体) downstream of activated integrins in osteoclast-like cells.
SUMOylation of Grb2 enhances the ERK (显示 EPHB2 抗体) activity by increasing its binding with Sos1 (显示 SOS1 抗体).
Data indicate that growth factor receptor (显示 RYK 抗体) protein binding protein 2 (Grb2) is upregulated and regulated by Forkhead Box D3 (Foxd3 (显示 FOXD3 抗体)), and pregulated Grb2 interacts with huntingtin (Htt (显示 HTT 抗体)).
The binding site of miR (显示 MLXIP 抗体)-433-3p was identified in the 3'UTR (显示 UTS2R 抗体) region of GRB2. Western blotting and FQ-PCR showed that miR (显示 MLXIP 抗体)-433-3p inhibited the mRNA and protein expression of GRB2.
study unravels a unique role of Grb2 in protecting the cytoskeletal architecture in AD-like conditions and presents a potential new strategy for controlling neurodegeneration
M. tuberculosis-initiated human mannose receptor signaling regulates macrophage recognition and vesicle trafficking by gamma Fc receptors, Grb2, and SHP-1.
Data indicate GRB2 as a direct target of miR (显示 MLXIP 抗体)-329 in pancreatic cancer cells, and expression of GRB2 was inversely correlated with miR (显示 MLXIP 抗体)-329 expression in pancreatic cancer patients.
EGFR (显示 EGFR 抗体) colocalization with GRB2 as assessed by PLA is not correlated with EGFR (显示 EGFR 抗体) expression levels or mutation status, defining a patient group that may show EGFR (显示 EGFR 抗体) pathway activation, as illustrated by its prognostic value.
Low GRB2 expression is associated with Breast Cancer.
Rab13 (显示 RAB13 抗体) activated the downstream AMPK (显示 PRKAA1 抗体) and blocked mTOR (显示 FRAP1 抗体) signaling by its functional interaction with Grb2 to regulate autophagy in human vascular endothelial cells.
ACTB (显示 ACTB 抗体), CDKN1B (显示 CDKN1B 抗体), GAPDH (显示 GAPDH 抗体), GRB2, RHOA (显示 RHOA 抗体) and SDCBP (显示 SDCBP 抗体) are potent reference genes in neuroendocrine tumors of the lung.
We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt (显示 AKT1 抗体). As well as defining a novel mechanism of Akt (显示 AKT1 抗体) phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2 (显示 FGFR2 抗体), Plc11 and Grb2 correlate with patient survival
Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (显示 SHC1 抗体) (Gads (显示 GRAP2 抗体)), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src (显示 SRC 抗体) homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 (显示 CD28 抗体) with variable affinity
in VSMCs exposed to hyperglycemia, IGF-I (显示 IGF1 抗体) stimulation of Shc (显示 SHC1 抗体) facilitates the transfer of Grb2 to p85 (显示 ARHGEF7 抗体) resulting in enhanced PI3K activation and AKT (显示 AKT1 抗体) phosphorylation leading to enhanced cell proliferation and migration
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
growth factor receptor-bound protein 2
, Growth factor receptor-bound protein 2
, SH2/SH3 adapter GRB2
, adapter protein GRB2
, protein Ash
, abundant SRC homology
, epidermal growth factor receptor-binding protein GRB2
, growth factor receptor-bound protein 3
, growth factor receptor bound protein 2