The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).[provided by RefSeq, Jan 2011].
Campla, Bocchero, Strickland, Nellissery, Advani, Ignatova, Srivastava, Aponte, Wang, Gumerson, Martemyanov, Artemyev, Pahlberg, Swaroop: "Frmpd1 Facilitates Trafficking of G-Protein Transducin and Modulates Synaptic Function in Rod Photoreceptors of Mammalian Retina." in: eNeuro, Vol. 9, Issue 5, (2022) (PubMed).
Kotak, Busso, Gönczy: "NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane." in: The EMBO journal, Vol. 33, Issue 16, pp. 1815-30, (2014) (PubMed).
Kotak, Busso, Gönczy: "Cortical dynein is critical for proper spindle positioning in human cells." in: The Journal of cell biology, Vol. 199, Issue 1, pp. 97-110, (2012) (PubMed).
Yasumi, Sakisaka, Hoshino, Kimura, Sakamoto, Yamanaka, Ohno, Takai: "Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division." in: The Journal of biological chemistry, Vol. 280, Issue 8, pp. 6761-5, (2005) (PubMed).