SARS-CoV-2 Spike Protein (BA.5 - Omicron, Trimer) (His tag)
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- 抗原 See all SARS-CoV-2 Spike 蛋白
- SARS-CoV-2 Spike
- 蛋白类型
- Recombinant
- 产品特性
- BA.5 - Omicron, Trimer
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宿主
- SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Omicron
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资源
- HEK-293 Cells
- 标记
- This SARS-CoV-2 Spike protein is labelled with His tag.
- 原理
- SARS-CoV-2 Spike Trimer Protein, His Tag (BA.5/Omicron) (Trehalose free) (MALS verified)
- 序列
- Val 16 - Pro 1213
- 产品特性
- SARS-CoV-2 Spike Trimer, His Tag (BA.5/Omicron) is expressed from human 293 cells (HEK293). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.5, GISAID clade: GRA). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
- 纯度
- 95,00 %
- 内毒素水平
- 1.0 EU per μg
- 质量等级
- MALS verified
- Top Product
- Discover our top product SARS-CoV-2 Spike 蛋白
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- 说明
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This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 137.8 kDa. The protein migrates as 160-190 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS
- 储存条件
- -80 °C
- 储存方法
- -70°C
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- 抗原
- SARS-CoV-2 Spike
- Abstract
- SARS-CoV-2 Spike 产品
- 别名
- E2 Protein, E2 glycoprotein precursor Protein, Surface Glycoprotein Protein, S Protein
- 背景
- Synonyms:Spike,S protein,Spike glycoprotein,S glycoprotein,Description:It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
- 分子量
- 137.8 kDa
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