Use your antibodies-online credentials, if available.
Human MET Protein expressed in Human Cells - ABIN2003241
Bottaro, Rubin, Faletto, Chan, Kmiecik, Vande Woude, Aaronson: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. in Science (New York, N.Y.) 1991
Show all 7 Pubmed References
HGF/c-MET pathway mediates VEGFR (显示 KDR 蛋白) inhibitor resistance and vascular remodeling in NSCLC.
Because c-Met is strongly associated with pathological grade, stage and disease-specific survival, c-Met levels may have potential to predict patient prognosis and to guide clinical diagnosis and treatment of patients with renal cell carcinoma (显示 MOK 蛋白)
miR-1 is downregulated in ovarian cancer tissues, and may play a tumor suppressive role by inhibiting c-Met expression and its effects on the regulation of cell proliferation, migration and invasion
Proto-oncogene proteins c-met (MET) mutations Y1248H and D1246N confer resistance in vitro and in vivo.
study highlights the role of tissue differentiation on pathological response to neoadjuvant chemotherapy in gastric cancer and shows no impact between FOXP3 (显示 FOXP3 蛋白), HER2 (显示 ERBB2 蛋白) and MET expression in terms of tumor regression grading
c-Met represents a prognostic marker in renal cell carcinoma.Furthermore, c-MET will play a decisive role as a possible target for targeted therapies in the era of personalised medicine. Especially for RCC, the dual inhibition of VEGF and c-MET tyrosine kinase in cases of metastatic, treatment-resistant tumours is gaining clinical relevance. The role of c-Met has not been fully elucidated for all subtypes of renal cell ca
c-MET is a promising marker in K-RAS WT patients with colorectal liver metastases
Results show that met protein is up-regulated with renal cell carcinoma (显示 MOK 蛋白) and associated with poor prognosis.
MET immunohistochemistry demonstrated 100% sensitivity and 70.4% specificity. Multivariate analyses showed that patients with METex14 skipping had a higher recurrence rate than those with ALK fusion (versus METex14 skipping) in stage I to IIIA disease; however, the differences in overall survival were not significant after adjustment for pathologic stage.
In conclusion, these findings indicate that CMs (显示 Cd2ap 蛋白) derived from primary culture of NPC (显示 NPC1 蛋白) fractions of BA liver contain a large amount of active HGF (显示 HGF 蛋白), which may activate hepatic stem/progenitor cells and promote the appearance of hepatocyte-like cells or their clusters through HGF/c-Met signaling.
Met has a role in promoting formation of double minute chromosomes induced by Sei-1 (显示 SERTAD1 蛋白) in NIH-3T3 murine fibroblasts
Genetic activation of the antioxidant transcription factor Nrf2 improves liver damage and repair in hepatocyte-specific c-met-deficient mice mainly through restoring a balance in the cellular redox homeostasis.
MET promoted the development of squamous tumors by stimulating the synthesis and release of ligands that activate the epidermal growth factor receptor (EGFR (显示 EGFR 蛋白)).
through the activation of EGFR, MET activation parallels a RAS pathway to contribute to human and mouse cutaneous cancers.
Results show that c-MET expression is significantly low in pancreatic neuroendocrine tumors (PNETs) and is under the regulation of Meg3-mediated transcriptional and epigenetic mechanisms which contributes to the pathogenesis of PNETs.
Findings indicate a role for the hepatocyte growth factor receptor HGFR/c-MET pathway in neutrophil recruitment and function and suggest that c-MET inhibitor co-treatment may improve responses to cancer immunotherapy in settings beyond c-MET-dependent tumors.
Results demonstrate a new mechanism for the modulation of synapse formation, whereby MET activation induces an alignment of presynaptic and postsynaptic elements that are necessary for assembly and formation of functional synapses by subsets of neocortical neurons that express MET/beta-catenin (显示 CTNNB1 蛋白) complex.
MET signaling regulates intestinal homeostasis and regeneration, as well as adenoma formation. These activities of MET are promoted by the stem cell CD44 (显示 CD44 蛋白) isoform CD44v4-10.
a c-Met/ETS-1 (显示 ETS1 蛋白)/matrix metalloproteinase-14 (MMP-14 (显示 MMP14 蛋白)) axis that controls VE-cadherin (显示 CDH5 蛋白) degradation, endothelial mesenchymal transition, and vascular abnormality.
We found the roles of hepatocyte growth factor (HGF (显示 HGF 蛋白)) signaling in stria vascularis development for the first time and that lack of HGF (显示 HGF 蛋白) signaling in the inner ear leads to profound hearing loss in the mouse. Our findings reveal a novel mechanism that may underlie human deafness DFNB39 (显示 HGF 蛋白) and DFNB97. Our findings reveal an additional example of context-dependent c-MET signaling diversity, required here for proper cellular inva
possible cooperative role of the EGF (显示 EGF 蛋白) and HGF (显示 HGF 蛋白) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.
, HGF/SF receptor
, SF receptor
, hepatocyte growth factor receptor
, met proto-oncogene tyrosine kinase
, proto-oncogene c-Met
, scatter factor receptor
, tyrosine-protein kinase Met
, HGF receptor c-Met