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Human MET Protein expressed in Human Cells - ABIN2003241
Bottaro, Rubin, Faletto, Chan, Kmiecik, Vande Woude, Aaronson: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. in Science (New York, N.Y.) 1991
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These results suggest that gastric cancer progression is not associated with a unique signaling pathway and that a feedback loop may exist between the HGF/c-Met and Notch1 (显示 NOTCH1 蛋白) signaling pathways, which may result in therapeutic resistance.
High c-met expression is associated with oral squamous cell carcinoma.
FOXO1 (显示 FOXO1 蛋白) serves as an important linker between HER2 (显示 ERBB2 蛋白) and MET signaling pathways through negative crosstalks and is a key regulator of the acquired lapatinib resistance in HER2 (显示 ERBB2 蛋白)-positive GC cells.
analysis of how the cMET blockade augments radiation therapy in patients with NF2 (显示 NF2 蛋白)
these findings highlight the relevance of cross-species protein interactions between murine feeder cells and human epithelial cells in 3T3-J2 co-culture and demonstrate that STAT6 (显示 STAT6 蛋白) phosphorylation occurs in response to MET activation in epithelial cells. However, STAT6 (显示 STAT6 蛋白) nuclear translocation does not occur in response to HGF (显示 HGF 蛋白), precluding the transcriptional activity of STAT6 (显示 STAT6 蛋白).
c-Met-activated Mesenchymal Stem Cells (MSC (显示 MSC 蛋白)) pre-exposed to hypoxia interact with PrPC (显示 PRNP 蛋白) at the site of ischemic injury to increase the efficiency of MSC (显示 MSC 蛋白) transplantation.
This study demonstrates that simultaneous inhibition of c-Met and Src (显示 SRC 蛋白) signaling in MD-MSCs triggers apoptosis and reveals vulnerable pathways that could be exploited to develop NF2 (显示 NF2 蛋白) therapies.
prolonged treatment of single HGF/c-Met or Hh inhibitor leads to resistance to these single inhibitors, likely because the single c-Met treatment leads to enhanced expression of Shh (显示 SHH 蛋白), and vice versa. Targeting both the HGF/c-Met and Hh pathways simultaneously overcame the resistance to the single-inhibitor treatment and led to a more potent antitumor effect in combination with the chemotherapy treatment.
We identified unique and tumor-specific tyrosine phosphorylation rewiring in tumors resistant to treatment with the irreversible third-generation EGFR (显示 EGFR 蛋白)-inhibitor, osimertinib, or the novel dual-targeting EGFR (显示 EGFR 蛋白)/Met antibody, JNJ-61186372.
TGF-beta (显示 TGFB1 蛋白) negatively controls the HGF/c-MET pathway by regulating of stemness in glioblastoma.
Data provide the first evidence of spontaneous bleeding in Par4 (显示 F2RL3 蛋白)(-/-) mice, suggest that a dam's first litter provides a greater hemostatic challenge than subsequent litters.
PAR-4 (显示 F2RL3 蛋白) is expressed in cardiac fibroblasts and is regulated by extracellular glucose and in diabetes mellitus.
SOCS1 (显示 SOCS1 蛋白) attenuates migration and invasion properties of hepatocellular carcinoma cells at least partly via modulation of MET-mediated epithelial-mesenchymal transition, and controls invasive tumor growth.
Met has a role in promoting formation of double minute chromosomes induced by Sei-1 (显示 SERTAD1 蛋白) in NIH-3T3 murine fibroblasts
Genetic activation of the antioxidant transcription factor Nrf2 improves liver damage and repair in hepatocyte-specific c-met-deficient mice mainly through restoring a balance in the cellular redox homeostasis.
MET promoted the development of squamous tumors by stimulating the synthesis and release of ligands that activate the epidermal growth factor receptor (EGFR (显示 EGFR 蛋白)).
through the activation of EGFR, MET activation parallels a RAS pathway to contribute to human and mouse cutaneous cancers.
Results show that c-MET expression is significantly low in pancreatic neuroendocrine tumors (PNETs) and is under the regulation of Meg3-mediated transcriptional and epigenetic mechanisms which contributes to the pathogenesis of PNETs.
Findings indicate a role for the hepatocyte growth factor receptor HGFR/c-MET pathway in neutrophil recruitment and function and suggest that c-MET inhibitor co-treatment may improve responses to cancer immunotherapy in settings beyond c-MET-dependent tumors.
possible cooperative role of the EGF (显示 EGF 蛋白) and HGF (显示 HGF 蛋白) pathways and indicate that cross-talk between their respective receptors may modulate mammary gland development in the cow
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.
, HGF/SF receptor
, SF receptor
, hepatocyte growth factor receptor
, met proto-oncogene tyrosine kinase
, proto-oncogene c-Met
, scatter factor receptor
, tyrosine-protein kinase Met
, HGF receptor c-Met