c-MET Protein (AA 956-1390) (GST tag,His tag)
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Quick Overview for c-MET Protein (AA 956-1390) (GST tag,His tag) (ABIN7317093)
抗原
See all c-MET (MET) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 956-1390
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标记
- This c-MET protein is labelled with GST tag,His tag.
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原理
- Recombinant Human c-MET/HGFR Protein (aa 956-1390, His & GST Tag)(Active)
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序列
- Lys956-Ser1390
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产品特性
- A DNA sequence encoding the human MET (P08581-1) (Lys956-Ser1390) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Biological Activity Comment
- The specific activity was determined to be 10 nmol/min/mg using MBP as substrate.2. Measured by its binding ability in a functional ELISA. Immobilized human HGFR (aa 956-1390) at 10 μg/ml (100 μl/well) can bind biotinylated human HGF-his with a linear range of 15.6-125 ng/ml.
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Met Proto-Oncogene (MET) (AA 25-932) protein (His-Avi Tag)
MET 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE, > 95 % as determined by HPLC
Met Proto-Oncogene (MET) (AA 25-930) (Active) protein (His tag)MET 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Met Proto-Oncogene (MET) (AA 25-932) (Active) protein (Biotin,His-Avi Tag)MET 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Met Proto-Oncogene (MET) (AA 25-932) (Active) protein (His tag,AVI tag,Biotin)MET 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Met Proto-Oncogene (MET) (AA 956-1080) protein (His-IF2DI Tag)MET 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Met Proto-Oncogene (MET) (AA 26-125) protein (GST tag)MET 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Met Proto-Oncogene (MET) (AA 25-932) protein (His tag)MET 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Met Proto-Oncogene (MET) (AA 25-932) protein (Fc Tag)MET 宿主: 人 宿主: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Met Proto-Oncogene (MET) (Active) protein (His tag)MET 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Met Proto-Oncogene (MET) (Active) protein (Fc Tag)MET 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE Active
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限制
- 仅限研究用
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状态
- Frozen, Liquid
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缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol, 3 mM DTT
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储存条件
- -20 °C
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储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- c-MET (MET) (Met Proto-Oncogene (MET))
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别名
- c-MET/HGFR
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背景
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Background: Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: AUTS9;c-Met;DFNB97;HGFR;RCCP2
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分子量
- 76.8 kDa
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途径
- RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
抗原
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