c-MET Protein (AA 956-1390) (GST tag,His tag)
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- 抗原 See all c-MET (MET) 蛋白
- c-MET (MET) (Met Proto-Oncogene (MET))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 956-1390
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This c-MET protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human c-MET/HGFR Protein (aa 956-1390, His & GST Tag)(Active)
- 序列
- Lys956-Ser1390
- 产品特性
- A DNA sequence encoding the human MET (P08581-1) (Lys956-Ser1390) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 10 nmol/min/mg using MBP as substrate.2. Measured by its binding ability in a functional ELISA. Immobilized human HGFR (aa 956-1390) at 10 μg/ml (100 μl/well) can bind biotinylated human HGF-his with a linear range of 15.6-125 ng/ml.
- Top Product
- Discover our top product MET 蛋白
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Met Proto-Oncogene (MET) (AA 25-932) protein (His-Avi Tag)
MET 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Met Proto-Oncogene (MET) (AA 25-932) protein (Fc Tag)MET 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Met Proto-Oncogene (MET) (AA 25-930) protein (His tag)MET 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Met Proto-Oncogene (MET) (AA 25-932) protein (His-Avi Tag,Biotin)MET 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Met Proto-Oncogene (MET) (AA 25-932) (Active) protein (His tag,AVI tag,Biotin)MET 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Met Proto-Oncogene (MET) (AA 956-1080) protein (His-IF2DI Tag)MET 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Met Proto-Oncogene (MET) (AA 26-125) protein (GST tag)MET 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Met Proto-Oncogene (MET) (Active) protein (His tag)MET 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Met Proto-Oncogene (MET) (Active) protein (Fc Tag)MET 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol, 3 mM DTT
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- c-MET (MET) (Met Proto-Oncogene (MET))
- 别名
- c-MET/HGFR (MET 产品)
- 别名
- AUTS9 Protein, HGFR Protein, RCCP2 Protein, c-Met Protein, AI838057 Protein, HGF Protein, Par4 Protein, Hgfr Protein, c-met Protein, MET Protein, C-MET Protein, met Protein, met-A Protein, MET proto-oncogene, receptor tyrosine kinase Protein, met proto-oncogene Protein, MET proto-oncogene, receptor tyrosine kinase L homeolog Protein, MET Protein, Met Protein, met.L Protein
- 背景
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Background: Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: AUTS9;c-Met;DFNB97;HGFR;RCCP2
- 分子量
- 76.8 kDa
- 途径
- RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
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