Poliovirus Receptor Protein (PVR) (AA 29-348) (His tag)
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- 抗原 See all Poliovirus Receptor (PVR) 蛋白
- Poliovirus Receptor (PVR)
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 29-348
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宿主
- 小鼠
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资源
- 人细胞
- 标记
- This Poliovirus Receptor protein is labelled with His tag.
- 原理
- Recombinant Mouse CD155/PVR Protein (aa 29-348, His Tag)(Active)
- 序列
- Asp29-Leu348
- 产品特性
- Recombinant Mouse Poliovirus Receptor is produced by our Mammalian expression system and the target gene encoding Asp29-Leu348 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized Human TIGIT-Fc(Cat: PKSH033510) at 5μg/ml(100 μl/well) can bind Mouse PVR-6His. The ED50 of Mouse PVR-6His is 35.3 ug/mL
- Top Product
- Discover our top product PVR 蛋白
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Poliovirus Receptor (PVR) (AA 21-343) protein (His-Avi Tag,Biotin)
PVR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor (PVR) (AA 21-343) protein (mFc Tag)PVR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor (PVR) (AA 21-343) protein (Fc Tag)PVR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC
Poliovirus Receptor (PVR) (AA 29-348) protein (His tag)PVR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor (PVR) (AA 21-343) protein (His-Avi Tag)PVR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC
Poliovirus Receptor (PVR) (AA 28-343) protein (His tag)PVR 宿主: 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor (PVR) (AA 21-343) protein (Fc Tag,Biotin)PVR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Poliovirus Receptor (PVR) protein (mFc-His Tag)PVR 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Poliovirus Receptor (PVR) (AA 28-343) (Active) protein (His tag)PVR 宿主: 猕猴 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Poliovirus Receptor (PVR) (AA 21-343) (Active) protein (Fc Tag)PVR 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Poliovirus Receptor (PVR)
- 别名
- CD155/PVR (PVR 产品)
- 别名
- PVR Protein, CD155 Protein, HVED Protein, NECL5 Protein, Necl-5 Protein, PVS Protein, TAGE4 Protein, 3830421F03Rik Protein, D7Ertd458e Protein, Taa1 Protein, Tage4 Protein, mE4 Protein, necl-5 Protein, poliovirus receptor Protein, PVR Protein, Pvr Protein
- 背景
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Background: Mouse poliovirus receptor (PVR, CD155) is a type I transmembrane (TM) glycoprotein that is a member of the nectin-related family of adhesion proteins within the immunoglobulin superfamily. It binds other molecules including vitronectin, Nectin3, DNAM1, CD96, and TIGIT, but does not bind homotypically. CD155 includes a 28 aa signal sequence, a 318 aa extracellular domain (ECD) with one N-terminal V-type and two C2-type Ig-like domains, a 24 aa TM segment and a 38 aa cytoplasmic tail. Epithelial, endothelial, and many immune cells show low CD155 expression. It is up-regulated on endothelia by IFNγ, and is highly expressed on immature thymocytes, lymph node dendritic cells, and tumor cells of epithelial and neuronal origin. On migrating cells, it is concentrated at the leading edge, where it binds basement membrane vitronectin, recruits Nectin-3-expressing cells, and cooperates with PDGF and integrin αvβ3 to promote cell migration. Binding of monocyte DNAM-1 to endothelial cell CD155 promotes transendothelial migration. Enhanced CD155 expression in tumor cells contributes to loss of contact inhibition and increased migration, but also allows tumor cell recognition and killing by DNAM-1or CD96 expressing NK cells.
Synonym: Poliovirus receptor, CD155 antigen, Nectin-like protein 5, Nectin-2, Tage4 receptor, Pvr, PVR, Necl5, CD155,3830421F03Rik,D7Ertd458e,HVED,mE4,necl-5,PVS,Taa1,Tage4
- 分子量
- 35.6 kDa
- UniProt
- Q8K094
- 途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome
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