p21 Protein (AA 2-164) (GST tag)
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- 抗原 See all p21 (CDKN1A) 蛋白
- p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
- 蛋白类型
- Recombinant
- 产品特性
- AA 2-164
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This p21 protein is labelled with GST tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MSEPAGDVRQ NPCGSKACRR LFGPVDSEQL SRDCDALMAG CIQEARERWN FDFVTETPLE GDFAWERVRG LGLPKLYLPT GPRRGRDELG GGRRPGTSPA LLQGTAEEDH VDLSLSCTLV PRSGEQAEGS PGGPGDSQGR KRRQTSMTDF YHSKRRLIFS KRKP
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product CDKN1A 蛋白
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
- 别名
- CDN1A (CDKN1A 产品)
- 别名
- CCND1 Protein, CDKN1A Protein, CAP20 Protein, CDKN1 Protein, CIP1 Protein, MDA-6 Protein, P21 Protein, SDI1 Protein, WAF1 Protein, p21CIP1 Protein, CDKI Protein, Cdkn1 Protein, Waf1 Protein, mda6 Protein, p21Cip1 Protein, p21WAF Protein, Cip1 Protein, UV96 Protein, p21 Protein, cip1 Protein, p16Xic2 Protein, sdi1 Protein, waf1 Protein, cap20 Protein, cdkn1 Protein, mda-6 Protein, p21cip1 Protein, si:ch1073-48m5.2 Protein, KRAS2 Protein, p21ras Protein, cyclin D1 Protein, cyclin dependent kinase inhibitor 1A Protein, cyclin-dependent kinase inhibitor 1A (P21) Protein, cyclin-dependent kinase inhibitor 1A Protein, cyclin-dependent kinase inhibitor 1A L homeolog Protein, cyclin-dependent kinase inhibitor 1 Protein, KRAS proto-oncogene, GTPase Protein, CCND1 Protein, CDKN1A Protein, Cdkn1a Protein, cdkn1a.L Protein, cki1 Protein, cdkn1a Protein, KRAS Protein
- 背景
- May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assbly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
- 分子量
- 45.5 kDa
- UniProt
- P38936
- 途径
- p53 Pathway, PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy
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