p21 产品
(Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
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This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010].
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Featured p21 Categories
p21 抗体
High quality antibodies with extensive validation data.
p21 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
p21 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended p21 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
- (7)
Cat. No.
ABIN3022006
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (6)
Cat. No.
ABIN7255634
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, PLA
Validations
- (2)
- (5)
Cat. No.
ABIN560309
Quantity
100 μg
Datasheet
Datasheet
Recommended p21 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966175
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6966176
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955163
Quantity
96 tests
Datasheet
Datasheet
Recommended p21 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122536
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122535
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1349005
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our p21 Products
: "Evidence that SARS-CoV-2 Induces Lung-Cell Senescence: Potential Impact on COVID-19 Lung Disease." in: American journal of respiratory cell and molecular biology, (2021) (PubMed).: "Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A." in: Molecular medicine reports, Vol. 22, Issue 5, pp. 3873-3885, (2021) (PubMed).
: "p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence." in: Matrix biology : journal of the International Society for Matrix Biology, (2019) (PubMed).
: "Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells." in: Cell biology and toxicology, (2019) (PubMed).
: "Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells." in: Experimental cell research, Vol. 370, Issue 2, pp. 292-302, (2018) (PubMed).
: "LncRNA GACAT3 acts as a competing endogenous RNA of HMGA1 and alleviates cucurbitacin B-induced apoptosis of gastric cancer cells." in: Gene, (2018) (PubMed).
: "Dicer1 downregulation by multiple myeloma cells promotes the senescence and tumor-supporting capacity and decreases the differentiation potential of mesenchymal stem cells." in: Cell death & disease, Vol. 9, Issue 5, pp. 512, (2018) (PubMed).
: "Cullin3/KCTD5 induces monoubiquitination of ΔNp63α and impairs its activity." in: FEBS letters, Vol. 592, Issue 13, pp. 2334-2340, (2018) (PubMed).
: "Radiation-induced premature cellular senescence involved in glomerular diseases in rats." in: Scientific reports, Vol. 8, Issue 1, pp. 16812, (2018) (PubMed).
: "DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 7, pp. E1224-E1233, (2017) (PubMed).
Synonyms and alternative names related to p21
cyclin D1 (CCND1), cyclin dependent kinase inhibitor 1A (CDKN1A), cyclin-dependent kinase inhibitor 1A (P21) (Cdkn1a), cyclin-dependent kinase inhibitor 1A (Cdkn1a), cyclin-dependent kinase inhibitor 1A L homeolog (cdkn1a.L), cyclin-dependent kinase inhibitor 1 (cki1), cyclin-dependent kinase inhibitor 1A (cdkn1a), cyclin dependent kinase inhibitor 1A (Cdkn1a), KRAS proto-oncogene, GTPase (KRAS), CAP20, cap20, CCND1, CDKI, CDKN1, Cdkn1, cdkn1, CDKN1A, CIP1, Cip1, cip1, KRAS2, MDA-6, mda-6, mda6, p16Xic2, P21, p21, p21CIP1, p21Cip1, p21cip1, p21ras, p21WAF, SDI1, sdi1, si:ch1073-48m5.2, UV96, WAF1, Waf1, waf1Protein level used designations for p21
- cyclin D1
- cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- CDK-interacting protein 1
- CDK-interaction protein 1
- DNA synthesis inhibitor
- cyclin-dependent kinase inhibitor 1
- melanoma differentiation associated protein 6
- wild-type p53-activated fragment 1
- melanoma differentiation-associated protein
- p21
- cyclin-dependent kinase inhibitor 1A (P21)
- cyclin dependent kinase inhibitor p16Xic2
- cip1
- p21
- waf1
- cyclin-dependent kinase inhibitor 1A
- p21/WAF1
- GTPase KRas
- Kirsten rat sarcoma viral (Kras-2) oncogene homolog
- v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
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