p21 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
(1 reference)-
- 抗原 See all p21 (CDKN1A) 蛋白
- p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
- 蛋白类型
- Recombinant
- 产品特性
- Transcript Variant 2
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This p21 protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
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- Recombinant human CDKN1A / p21WAF1 (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product CDKN1A 蛋白
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Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 2-164) protein (His tag)
CDKN1A 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 2-164) protein (His-IF2DI Tag)CDKN1A 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 1-164) protein (GST tag)CDKN1A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 65-164) protein (GST tag)CDKN1A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 2-164) protein (His tag)Crystallography grade CDKN1A 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 2-159) protein (His tag)Crystallography grade CDKN1A 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 应用备注
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
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The tag is located at the C-terminal.
- 限制
- 仅限研究用
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- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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: "Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 34, pp. 13799-804, (2012) (PubMed).
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: "Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 34, pp. 13799-804, (2012) (PubMed).
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- 抗原
- p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
- 别名
- Cdkn1a,p21waf1 (CDKN1A 产品)
- 别名
- CCND1 Protein, CDKN1A Protein, CAP20 Protein, CDKN1 Protein, CIP1 Protein, MDA-6 Protein, P21 Protein, SDI1 Protein, WAF1 Protein, p21CIP1 Protein, CDKI Protein, Cdkn1 Protein, Waf1 Protein, mda6 Protein, p21Cip1 Protein, p21WAF Protein, Cip1 Protein, UV96 Protein, p21 Protein, cip1 Protein, p16Xic2 Protein, sdi1 Protein, waf1 Protein, cap20 Protein, cdkn1 Protein, mda-6 Protein, p21cip1 Protein, si:ch1073-48m5.2 Protein, KRAS2 Protein, p21ras Protein, cyclin D1 Protein, cyclin dependent kinase inhibitor 1A Protein, cyclin-dependent kinase inhibitor 1A (P21) Protein, cyclin-dependent kinase inhibitor 1A Protein, cyclin-dependent kinase inhibitor 1A L homeolog Protein, cyclin-dependent kinase inhibitor 1 Protein, KRAS proto-oncogene, GTPase Protein, CCND1 Protein, CDKN1A Protein, Cdkn1a Protein, cdkn1a.L Protein, cki1 Protein, cdkn1a Protein, KRAS Protein
- 背景
- This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.
- 分子量
- 17.9 kDa
- NCBI登录号
- NP_510867
- 途径
- p53 Pathway, PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy
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