NUDT1 抗体
-
- 抗原 See all NUDT1 抗体
- NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This NUDT1 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 人
- 纯化方法
- Purified by Protein A.
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human NUDT1 (NP_945192.1).
- 亚型
- IgG
- Top Product
- Discover our top product NUDT1 Primary Antibody
-
-
- 应用备注
-
WB 1:300-5000
IHC-P 1:200-400
IP(1-2 μg)
IHC() - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
-
- 抗原
- NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
- 别名
- NUDT1 (NUDT1 产品)
- 别名
- mutT antibody, nudT1 antibody, MTH1 antibody, Mth1 antibody, 7,8-dihydro-8-oxoguanine triphosphatase antibody, nudix hydrolase 1 antibody, nudix (nucleoside diphosphate linked moiety X)-type motif 1 antibody, mth1 antibody, Tsp_07498 antibody, nudt1 antibody, 8odp antibody, NUDT1 antibody, Nudt1 antibody
- 背景
-
Synonyms: NUDT1,MTH1
Background: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
- 基因ID
- 4521
- UniProt
- P36639
-