NUDT1 产品
(Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
Categories
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008].
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Featured NUDT1 Categories
NUDT1 抗体
High quality antibodies with extensive validation data.
NUDT1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
NUDT1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NUDT1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
IHC, ELISA, IF
Validations
- (3)
Cat. No.
ABIN7142858
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (3)
Cat. No.
ABIN518070
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN7256838
Quantity
200 μL
Datasheet
Datasheet
Recommended NUDT1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969035
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730563
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6226065
Quantity
96 tests
Datasheet
Datasheet
Recommended NUDT1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1313165
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124237
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3088099
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our NUDT1 Products
: "The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress." in: Mutation research, Vol. 808, pp. 10-19, (2019) (PubMed).: "The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia." in: BMC cancer, Vol. 18, Issue 1, pp. 1190, (2019) (PubMed).
: "Potent and specific MTH1 inhibitors targeting gastric cancer." in: Cell death & disease, Vol. 10, Issue 6, pp. 434, (2019) (PubMed).
: "Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue." in: DNA repair, pp. 102644, (2019) (PubMed).
: "Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. ..." in: Nature communications, Vol. 9, Issue 1, pp. 250, (2018) (PubMed).
: "Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway." in: Journal of lipid research, Vol. 59, Issue 5, pp. 830-842, (2018) (PubMed).
: "Validating the concept of mutational signatures with isogenic cell models." in: Nature communications, Vol. 9, Issue 1, pp. 1744, (2018) (PubMed).
: "hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia." in: Oncogenesis, Vol. 5, Issue 12, pp. e275, (2016) (PubMed).
: "Human MutT homologue 1 mRNA overexpression correlates to poor response of multiple myeloma." in: International journal of hematology, Vol. 105, Issue 3, pp. 318-325, (2016) (PubMed).
: "MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways." in: Oncogene, Vol. 34, Issue 20, pp. 2586-96, (2015) (PubMed).
Synonyms and alternative names related to NUDT1
7,8-dihydro-8-oxoguanine triphosphatase (mth1), 7,8-dihydro-8-oxoguanine triphosphatase (Tsp_07498), nudix hydrolase 1 (nudt1), 7,8-dihydro-8-oxoguanine triphosphatase (8odp), nudix hydrolase 1 (NUDT1), nudix (nucleoside diphosphate linked moiety X)-type motif 1 (Nudt1), nudix hydrolase 1 (Nudt1), MTH1, Mth1, mutT, nudT1Protein level used designations for NUDT1
- 7,8-dihydro-8-oxoguanine triphosphatase
- 2-hydroxy-dATP diphosphatase
- 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase
- 8-oxo-7,8-dihydroguanosine triphosphatase
- 8-oxo-dGTPase
- mutT human homolog 1
- nucleoside diphosphate-linked moiety X motif 1
- nucleoside diphosphate-linked moiety X-type motif 1
- nudix motif 1
- 8-oxo-7,8-dihydro-2'-dGTPase
- mutT human homolog (8-oxo-dGTPase)
- nudix-type motif 1
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