LATS2 抗体 (Internal Region)
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- 抗原 See all LATS2 抗体
- LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))
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抗原表位
- Internal Region
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适用
- 小鼠, 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LATS2 antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- LATS2 Antibody detects endogenous levels of total LATS2.
- 预测反应
- Pig,Horse,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human LATS2, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product LATS2 Primary Antibody
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anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (pSer83) antibody
LATS2 适用: 小鼠, 人, 大鼠 ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 195-224) antibodyLATS2 适用: 小鼠, 人 ELISA, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1-100) antibodyLATS2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) antibodyLATS2 适用: 小鼠, 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (pSer83) antibodyLATS2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal ST-3B11 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1000-1027), (C-Term) antibodyLATS2 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB40566 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 适用: 小鼠, 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1022-1140) antibodyLATS2 适用: 斑马鱼 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 适用: 人 IHC (p) 宿主: 兔 Polyclonal RB3032 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 541-590) antibodyLATS2 适用: 小鼠, 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))
- 别名
- LATS2 (LATS2 产品)
- 别名
- 4932411G09Rik antibody, AV277261 antibody, AW228608 antibody, KPM antibody, lats2 antibody, large tumor suppressor kinase 2 antibody, large tumor suppressor 2 antibody, LATS2 antibody, Lats2 antibody, lats2 antibody
- 背景
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Description: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
Gene: LATS2
- 分子量
- 150 kDa
- 基因ID
- 26524
- UniProt
- Q9NRM7
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