LATS2 抗体 (C-Term)
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Quick Overview for LATS2 抗体 (C-Term) (ABIN1881491)
抗原
See all LATS2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1000-1027, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This Mouse Lats2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1000-1027 amino acids from the C-terminal region of mouse Lats2.
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亚型
- Ig Fraction
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anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (pSer83) antibody
LATS2 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1-100) antibodyLATS2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1022-1140) antibodyLATS2 适用: 斑马鱼 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 适用: 人 IHC (p) 宿主: 兔 Polyclonal RB3032 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 541-590) antibodyLATS2 适用: 人, 小鼠 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1000-1027) antibodyLATS2 适用: 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:2000. IHC-P: 1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse." in: Molecular and cellular biology, Vol. 29, Issue 23, pp. 6309-20, (2009) (PubMed).
: "Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 45, pp. 14309-22, (2009) (PubMed).
: "The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass." in: Developmental cell, Vol. 16, Issue 3, pp. 398-410, (2009) (PubMed).
: "Lats2 is a negative regulator of myocyte size in the heart." in: Circulation research, Vol. 103, Issue 11, pp. 1309-18, (2008) (PubMed).
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: "Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse." in: Molecular and cellular biology, Vol. 29, Issue 23, pp. 6309-20, (2009) (PubMed).
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- LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))
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别名
- Lats2
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背景
- Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity).
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分子量
- 115472
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NCBI登录号
- NP_056586
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UniProt
- Q7TSJ6
抗原
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