-
- 抗原 See all LATS2 抗体
- LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))
-
抗原表位
- AA 1000-1027
-
适用
- 小鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This LATS2 antibody is un-conjugated
-
应用范围
- ELISA, Western Blotting (WB)
- 纯化方法
- Antigen affinity purified
- 免疫原
- A portion of amino acids 1000-1027 from the mouse protein was used as the immunogen for this Lats2 antibody.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product LATS2 Primary Antibody
-
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (pSer83) antibody
LATS2 适用: 小鼠, 人, 大鼠 ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 195-224) antibodyLATS2 适用: 小鼠, 人 ELISA, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1-100) antibodyLATS2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) antibodyLATS2 适用: 小鼠, 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (pSer83) antibodyLATS2 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal ST-3B11 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1000-1027), (C-Term) antibodyLATS2 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB40566 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 适用: 小鼠, 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1022-1140) antibodyLATS2 适用: 斑马鱼 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 适用: 人 IHC (p) 宿主: 兔 Polyclonal RB3032 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 541-590) antibodyLATS2 适用: 小鼠, 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- Titration of the Lats2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Aliquot the Lats2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
- 抗原
- LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))
- 别名
- Lats2 (LATS2 产品)
- 别名
- 4932411G09Rik antibody, AV277261 antibody, AW228608 antibody, KPM antibody, lats2 antibody, large tumor suppressor kinase 2 antibody, large tumor suppressor 2 antibody, LATS2 antibody, Lats2 antibody, lats2 antibody
- 背景
- Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity).
- UniProt
- Q7TSJ6
-
You are here:
