LATS2 抗体 (AA 1000-1027)
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北京 101111
Quick Overview for LATS2 抗体 (AA 1000-1027) (ABIN3031594)
抗原
See all LATS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1000-1027
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 1000-1027 from the mouse protein was used as the immunogen for this Lats2 antibody.
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亚型
- Ig Fraction
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anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (pSer83) antibody
LATS2 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1-100) antibodyLATS2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1000-1027), (C-Term) antibodyLATS2 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB40566 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1022-1140) antibodyLATS2 适用: 斑马鱼 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 适用: 人 IHC (p) 宿主: 兔 Polyclonal RB3032 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 541-590) antibodyLATS2 适用: 人, 小鼠 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Titration of the Lats2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Lats2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))
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别名
- Lats2
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背景
- Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor (By similarity).
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UniProt
- Q7TSJ6
抗原
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