LATS2 抗体 (pSer83)
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北京 101111
Quick Overview for LATS2 抗体 (pSer83) (ABIN753568)
抗原
See all LATS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer83
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特异性
- This phosphorylation site is homologous to that of Ser82 in Mouse and Ser83 Rat.
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic phosphopeptide derived from human LATS2 around the phosphorylation site of Ser83
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亚型
- IgG
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anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1-100) antibody
LATS2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1000-1027), (C-Term) antibodyLATS2 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB40566 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1022-1140) antibodyLATS2 适用: 斑马鱼 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 适用: 人 IHC (p) 宿主: 兔 Polyclonal RB3032 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 541-590) antibodyLATS2 适用: 人, 小鼠 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1000-1027) antibodyLATS2 适用: 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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: "Dysregulation of YAP by the Hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence." in: Oncotarget, Vol. 9, Issue 2, pp. 2175-2192, (2018) (PubMed).
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: "Dysregulation of YAP by the Hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence." in: Oncotarget, Vol. 9, Issue 2, pp. 2175-2192, (2018) (PubMed).
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- LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))
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别名
- LATS2
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背景
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Synonyms: KPM, Serine/threonine-protein kinase LATS2, Kinase phosphorylated during mitosis protein, Large tumor suppressor homolog 2, Serine/threonine-protein kinase kpm, Warts-like kinase, LATS2
Background: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
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基因ID
- 26524
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UniProt
- Q9NRM7
抗原
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