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Lamin A/C 抗体 (C-Term)

Name: Lamin A/C 抗体 (C-Term)
SKU: ABIN1108014
Availability: OutOfStock

LMNA 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Immunohistochemistry with Lamin A/C Polyclonal Antibody (Lamin A/C 抗体 (C-Term))

IHC (p)

1 image

产品编号 ABIN1108014

发货至: 中国

Datasheet as PDF

抗原 See all Lamin A/C (LMNA) 抗体

Lamin A/C (LMNA)
抗原表位
10

9

8

8

8

7

7

6

6

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
148

82

77

26

15

13

8

7

6

6

6

4

4

3

3

2

2

1

1

1

1

1

1
人, 小鼠, 大鼠
宿主
113

43

3

1
兔
Compatible Secondaries
克隆类型
108

52
多克隆
标记
114

11

9

8

4

4

2

2

1

1

1

1

1

1
This Lamin A/C antibody is un-conjugated
应用范围
126

55

52

49

32

29

29

24

13

7

3

2

2

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

特异性

This antibody detects Lamin-A/C (LMNA) at C-term. No cross reactivity with other proteins.

交叉反应（详细）

Species reactivity (tested):Human, mouse, rat

纯化方法

Immunogen affinity purified

免疫原

Synthetic peptide corresponding to a sequence at the C-terminal of human Lamin A/C .Remarks: Sequence is identical to the related rat and mouse sequence.

亚型

IgG

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anti-Lamin A/C (LMNA) antibody
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应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
溶解方式

0.2 mL of distilled water will yield a concentration of 500 μg/mL.

缓冲液

5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3

储存液

Sodium azide, Thimerosal (Merthiolate)

注意事项

This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
抗原

Lamin A/C (LMNA)

别名

Lamin-A/C (LMNA) (LMNA 产品)

别名

CDCD1 antibody, CDDC antibody, CMD1A antibody, CMT2B1 antibody, EMD2 antibody, FPL antibody, FPLD antibody, FPLD2 antibody, HGPS antibody, IDC antibody, LDP1 antibody, LFP antibody, LGMD1B antibody, LMN1 antibody, LMNC antibody, LMNL1 antibody, PRO1 antibody, Dhe antibody, 2459 antibody, 74/76 antibody, CG6944 antibody, D5 antibody, DM[[O]] antibody, Dm antibody, Dm(0) antibody, Dm0 antibody, Dm1 antibody, Dm2 antibody, DmLamin antibody, DmO antibody, Dm[[0]] antibody, Dm[[1]] antibody, Dm[[2]] antibody, Dm[[mit]] antibody, Dm[[o]] antibody, Dmel\\CG6944 antibody, Dmo antibody, LAM antibody, Lam Dm[[0]] antibody, Lam(Dm0) antibody, LamDm[[0]] antibody, LamDm[[o]] antibody, Lam[[Dm0]] antibody, Lamin Dm[[0]] antibody, jf27 antibody, l(2)04643 antibody, l(2)25Ec antibody, l(2)gdh-7 antibody, l(2)gdh7 antibody, l(2)jf27 antibody, lam antibody, lamDm0 antibody, lamDm[[0]] antibody, lamin antibody, lamin Dm0 antibody, lamin Dm[[0]] antibody, misg antibody, nlam antibody, cb948 antibody, fk66d12 antibody, wu:fk66d12 antibody, lmna-A antibody, fpl antibody, idc antibody, lfp antibody, cddc antibody, emd2 antibody, fpld antibody, hgps antibody, ldp1 antibody, lmn1 antibody, lmnc antibody, pro1 antibody, cdcd1 antibody, cmd1a antibody, cmt2b1 antibody, lgmd1b antibody, Lamin-A antibody, lamin-L(III)-like antibody, lamin A/C antibody, lamin A antibody, Lamin antibody, lamin A/C L homeolog antibody, lamin-L(III)-like antibody, LMNA antibody, Lmna antibody, Lam antibody, lmna antibody, lmna.L antibody, LMINA antibody

背景

Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A,B and C.The lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C. Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.Synonyms: 70 kDa Lamin, LMN1, LMNA, Lamin A, Lamin A + C, Lamin-A/C, NY-REN-32, NYREN32, Nuclear Envelope Marker, Renal carcinoma antigen NY-REN-32

基因ID

4000

NCBI登录号

NP_005563

UniProt

P02545

途径

Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus