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- 抗原 See all CD130/gp130 (IL6ST) 抗体
- CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This CD130/gp130 antibody is conjugated to PE
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应用范围
- Flow Cytometry (FACS)
- 交叉反应 （详细）
- Species reactivity (tested):Mouse
- 免疫原
- Mouse CD130 transfected cells
- 克隆位点
- RMb1
- 亚型
- IgG2a
- Top Product
- Discover our top product IL6ST Primary Antibody
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anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 392-566) antibody
IL6ST 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 238-500) antibodyIL6ST 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 73-231) antibodyIL6ST 适用: 人, 猴 WB, IHC, ELISA, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 8D4D2 unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 26-323) antibodyIL6ST 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 871-899), (C-Term) antibodyIL6ST 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB17993 unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 651-750) antibodyIL6ST 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (pSer782) antibodyIL6ST 适用: 人, 大鼠 WB, ELISA, IF (p), ICC, IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 678-857) antibodyKO Validated IL6ST 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibodyIL6ST 适用: 人 WB, IHC, ELISA, FACS, IP, Func 宿主: 小鼠 Monoclonal B-P4 unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (C-Term) antibodyIL6ST 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 缓冲液
- 50 tests in 1 mLvolume of PBS, 0.09 % NaN3, 1 % BSA
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2 - 8 °C.
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- 抗原
- CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
- 别名
- CD130 / IL6ST (IL6ST 产品)
- 别名
- CD130 antibody, CDW130 antibody, GP130 antibody, IL-6RB antibody, 5133400A03Rik antibody, AA389424 antibody, BB405851 antibody, D13Ertd699e antibody, gp130 antibody, Ac1055 antibody, Gp130 antibody, Il-6rb antibody, IL-6 antibody, interleukin 6 signal transducer antibody, IL6ST antibody, Il6st antibody, il6st antibody
- 背景
- The interleukin-6 (IL-6) cytokine family, including IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and B-cell stimulatory factor 3, are also known as gp130 cytokines because they all share gp130 as a common transducer protein within their functional receptor complexes. In the case of IL-6, binding of the ligand to its specific a-receptor (IL-6Ra/CD126) induces dimerization of gp130, activation of the gp130-associated Janus kinases Jak1, Jak2 and Tyk2 and phosphorylation of gp130 at cytoplasmic tyrosine residues. These phosphotyrosines serve as docking sites for SH2-domain-containing proteins such as STAT1, STAT3, the protein tyrosine phosphatase SHP2 and the suppressor of cytokine signalling 3 (SOCS3). The subsequently tyrosine phosphorylated STAT homo- or heterodimers translocate to the nucleus where they bind to enhancer sequences of IL-6-inducible genes. Both IL-6Ra and gp130 have soluble forms. Although soluble gp130 inhibits the effect of IL-6, the soluble IL-6Ra promotes the effect of IL-6.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta
- 基因ID
- 10090
- UniProt
- Q00560
- 途径
- JAK/STAT Signaling, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints
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