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Biallelic AAGGG expansion in RFC1 is a frequent cause of late-onset ataxia.
Human CTF18-RFC clamp-loader complexed with non-synthesising POLE efficiently loads the PCNA sliding clamp.
RFC depletion had a negative impact on LANA's ability to replicate and maintain viral DNA in cells containing artificial KSHV episomes or in infected cells, leading to loss of virus.
phosphorylation of serine 51 on hLigI plays a critical role in regulating the interaction between hLigI and RFC, which is required for efficient DNA replication and repair.
report that the large subunit (RFC1) of replication factor C is cleaved in Hutchinson-Gilford progeria syndrome cells, leading to the production of a truncated RFC1 of ~ 75 kDa
We identified a variant in each of 3 genes (RFC1, SCN1A, ANPEP) potentially implicated in susceptibility to severe neurological complications in West Nile Virus disease.
Small interfering RNA-mediated knockdown of RFC1 impairs upstream removal of UV lesions and abrogates the downstream recruitment of DNA polymerase delta.
analysis of the DNA-bound BRCA1 C-terminal region structure from human replication factor C p140 and model of the protein-DNA complex
interaction with histone deacetylase HDAC1
RFC (p140) has an important role as a regulator of transcription and NF-kappaB activity
destabilization of the RF-C complex by CDKs may inactivate the RF-C complex at the end of S phase
NMR resonance assignments of the BRCT region of the large subunit
Ctf18-RFC interacts physically with pol eta, which allows DNA replication forks to overcome interference by various template structures, including damaged DNA and DNA-protein complexes that maintain chromosome cohesion
Data show that replication factor C (RFC), via several stimulatory motifs per molecule, potently activates flap endonuclease 1 (FEN1), making RFC a critical partner with FEN1 for the processing of eukaryotic Okazaki fragments.
a mutant version of hLigI, which mimics the hyperphosphorylated M-phase form of hLigI, does not interact with and is not inhibited by RFC, demonstrating that inhibition of ligation is dependent upon the interaction between hLigI and RFC
required for double-strand break repair during meiotic homologous recombination
RFC1 plays critical roles in abscisic acid-mediated homologous recombination in Arabidopsis.
That RFC1 is found in divergent eukaryotes suggests a previously unrecognized and highly conserved role for DNA synthesis in discriminating between recombination pathways.
results suggest that RFC1 helps mediate genomic stability and transcriptional gene silencing in Arabidopsis thaliana
Dada suggest that AtRFC1 plays an important role in embryo development in Arabidopsis thaliana.
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
A1 140 kDa subunit
, DNA-binding protein PO-GA
, MHC binding factor, beta
, RF-C 140 kDa subunit
, activator 1 140 kDa subunit
, activator 1 large subunit
, activator 1 subunit 1
, replication factor C 140 kDa subunit
, replication factor C large subunit
, replication factor C subunit 1
, replication factor C1
, ISRE-binding protein
, differentiation-specific element-binding protein
, replication factor C 1
, replication factor C, 140 kDa