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2B4 Protein (AA 1-221) (His tag)

CD244 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN7505708
发货至: 中国
  • 抗原 See all 2B4 (CD244) 蛋白
    2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))
    蛋白类型
    Recombinant
    产品特性
    AA 1-221
    宿主
    • 17
    • 7
    • 3
    资源
    • 11
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    HEK-293 Cells
    标记
    This 2B4 protein is labelled with His tag.
    序列
    Met1-Arg221
    产品特性
    A DNA sequence encoding the Human 2B4 protein (Q9BZW8) (Met1-Arg221) was expressed with a C-His.
    纯度
    > 95 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product CD244 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    Lyophilized from sterile PBS, pH 7.4.
    Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization.
    储存条件
    4 °C,-20 °C,-80 °C
    储存方法
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    有效期
    12 months
  • 抗原
    2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))
    别名
    2B4 (CD244 产品)
    别名
    CD244 Protein, 2B4 Protein, NAIL Protein, NKR2B4 Protein, Nmrk Protein, SLAMF4 Protein, C9.1 Protein, F730046O15Rik Protein, Ly90 Protein, CD244 molecule Protein, CD244 natural killer cell receptor 2B4 Protein, CD244 Protein, Cd244 Protein
    背景

    Abbreviation: 2B4;CD244

    Target Synonym: Natural killer cell receptor 2B4;NK cell activation-inducing ligand;NAIL;NKR2B4;h2B4;SLAM family member 4;SLAMF4;CD244;2B4

    Background: The CD244 antigen; also known as 2B4; is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production; which is expressed on all NK cells; a subpopulation of T cells; monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor; human 2B4 can effectively activate and enhance NK cell–mediated cytotoxicity; induce secretion of IFN-γ and matrix metalloproteinases (MMPs); as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2; CD48; CD58; CD84; Ly-9; and SLAM; 2B4 (CD244) is expressed on all human NK cells; a subpopulation of T cells; basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity; induces secretion of IFN-gamma and matrix metalloproteinases; and NK cell invasiveness.

    分子量

    Calculated MW: 24.2 kDa

    Observed MW: 40 kDa

    UniProt
    Q9BZW8
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