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- 抗原 See all 2B4 (CD244) 蛋白
- 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- 人细胞
- 标记
- This 2B4 protein is labelled with His tag.
- 原理
- Recombinant Mouse 2B4/CD244 Protein (His Tag)
- 序列
- Gln20-Asn221
- 产品特性
- Recombinant Mouse Natural killer cell receptor 2B4 is produced by our Mammalian expression system and the target gene encoding Gln20-Asn221 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product CD244 蛋白
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Natural Killer Cell Receptor 2B4 (CD244) (AA 22-221) protein (His tag)
CD244 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Natural Killer Cell Receptor 2B4 (CD244) (AA 22-221) protein (Fc Tag)CD244 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Natural Killer Cell Receptor 2B4 (CD244) (AA 22-221) protein (His-Avi Tag,Biotin)CD244 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Natural Killer Cell Receptor 2B4 (CD244) protein (mFc-His Tag)CD244 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Natural Killer Cell Receptor 2B4 (CD244) (AA 22-221) protein (His tag,AVI tag,Biotin)CD244 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Natural Killer Cell Receptor 2B4 (CD244) (AA 125-224) protein (GST tag)CD244 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Natural Killer Cell Receptor 2B4 (CD244) (AA 1-365) protein (GST tag)CD244 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Natural Killer Cell Receptor 2B4 (CD244) (AA 251-370) protein (His tag)Crystallography grade CD244 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Natural Killer Cell Receptor 2B4 (CD244) (AA 248-397) protein (His tag)Crystallography grade CD244 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Natural Killer Cell Receptor 2B4 (CD244) (AA 22-229) protein (His tag)Crystallography grade CD244 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))
- 别名
- 2B4/CD244 (CD244 产品)
- 别名
- CD244 Protein, 2B4 Protein, NAIL Protein, NKR2B4 Protein, Nmrk Protein, SLAMF4 Protein, C9.1 Protein, F730046O15Rik Protein, Ly90 Protein, CD244 molecule Protein, CD244 natural killer cell receptor 2B4 Protein, CD244 Protein, Cd244 Protein
- 背景
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Background: Natural killer cell receptor 2B4 (2B4/CD244)is a 66 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family. SLAM family proteins have an extracellular domain (ECD) with two or four Ig-like domains and at least two cytoplasmic immunoreceptor tyrosine-based switch motifs (ITSMs). 2B4 interacts with CD48, while other SLAM family proteins interact in a homophilic manner. The mouse 2B4 cDNA encodes a 397 amino acid (aa) precursor that includes a 19 aa signal sequence, a 207 aa ECD with one Ig-like V-type and one C2-type Ig-like domain, a 21 aa transmembrane segment, and a 150 aa cytoplasmic domain with four ITSMs. Within the ECD, mouse 2B4 shares 46 % and 68 % aa sequence identity with human and rat 2B4, respectively. 2B4/CD48 signaling cooperates with other receptor systems to either promote or inhibit NK and CD8+ T cell activation. The inhibitory activities are distinct from those of MHC I restricted inhibitory NK cell receptors. Ligation of 2B4 with antibodies or CD48 constructs can directly trigger inhibitory signaling or disrupt an inhibitory interaction, leading to cellular activation. 2B4 can also induce signaling through CD48.
Synonym: Natural killer cell receptor 2B4, NK cell type I receptor protein 2B4, NKR2B4, SLAM family member 4, SLAMF4, Signaling lymphocytic activation molecule 4, CD244
- 分子量
- 23.5 kDa
- UniProt
- Q07763
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