MPL Protein (Fc Tag)
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- 抗原 See all MPL 蛋白
- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This MPL protein is labelled with Fc Tag.
- 原理
- Recombinant Human c-MPL with C-terminal human Fc tag
- 特异性
- C-MPL (Gln26-Ala490) hFc (Glu99-Ala330)
- 产品特性
- Extracellular Domain Protein
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product MPL 蛋白
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Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-491) protein (His tag)
MPL 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-482) protein (His tag)MPL 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-635) protein (MBP tag,His tag)Crystallography grade MPL 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 1-635) protein (GST tag)MPL 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-491) protein (His tag)MPL 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Myeloproliferative Leukemia Virus Oncogene (MPL) protein (His tag)MPL 宿主: 大鼠 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
- 别名
- c-MPL (MPL 产品)
- 别名
- C-MPL Protein, CD110 Protein, MPLV Protein, THCYT2 Protein, TPOR Protein, TPO-R Protein, c-mpl Protein, c-mpl-I Protein, c-mpl-II Protein, hlb219 Protein, MPL Protein, mpll Protein, tpor Protein, tpor.b Protein, MPL proto-oncogene, thrombopoietin receptor Protein, myeloproliferative leukemia virus oncogene Protein, MPL Protein, Mpl Protein, mpl Protein
- 背景
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C-MPL, CD110, MPLV, THCYT2, THPOR, TPORIn 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation.
Description: The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008] - 分子量
- predicted molecular mass of 78.5 kDa after removal of the signal peptide.The apparent molecular mass of c-MPL-hFc is 100-130 kDa due to glycosylation.
- UniProt
- P40238
- 途径
- JAK/STAT Signaling
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