MPL 产品
(Myeloproliferative Leukemia Virus Oncogene (MPL))
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In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008].
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Featured MPL Categories
MPL 抗体
High quality antibodies with extensive validation data.
MPL ELISA试剂盒
Reliable ELISA kits for a wide range of species.
MPL 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MPL 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7440170
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (2)
- (3)
Cat. No.
ABIN969542
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS, IHC, ICC, Neut
Validations
- (4)
Cat. No.
ABIN5611182
Quantity
0.1 mg
Datasheet
Datasheet
Recommended MPL ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957947
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5510636
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1117542
Quantity
96 tests
Datasheet
Datasheet
Recommended MPL 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275276
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (3)
Cat. No.
ABIN3113551
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275277
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our MPL Products
: "Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis." in: Leukemia, (2017) (PubMed).: "Aerobic exercise in humans mobilizes HSCs in an intensity-dependent manner." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 122, Issue 1, pp. 182-190, (2017) (PubMed).
: "Mouse monoclonal antibodies against human c-Mpl and characterization for flow cytometry applications." in: Hybridoma (2005), Vol. 29, Issue 2, pp. 103-13, (2010) (PubMed).
: "Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 11781-91, (2009) (PubMed).
: "Genetic mutations associated with cigarette smoking in pancreatic cancer." in: Cancer research, Vol. 69, Issue 8, pp. 3681-8, (2009) (PubMed).
: "An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis." in: Blood, Vol. 92, Issue 6, pp. 1981-8, (1998) (PubMed).
: "Thrombopoietin and erythropoietin activate inside-out signaling of integrin and enhance adhesion to immobilized fibronectin in human growth-factor-dependent hematopoietic cells." in: Annals of hematology, Vol. 75, Issue 5-6, pp. 207-13, (1998) (PubMed).
: "Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit." in: Blood, Vol. 88, Issue 6, pp. 2026-32, (1996) (PubMed).
Synonyms and alternative names related to MPL
MPL proto-oncogene, thrombopoietin receptor (MPL), myeloproliferative leukemia virus oncogene (Mpl), MPL proto-oncogene, thrombopoietin receptor (Mpl), MPL proto-oncogene, thrombopoietin receptor (mpl), C-MPL, c-mpl, c-mpl-I, c-mpl-II, CD110, hlb219, MPL, mpll, MPLV, THCYT2, TPO-R, TPOR, tpor, tpor.bProtein level used designations for MPL
- TPO-R
- myeloproliferative leukemia protein
- proto-oncogene c-Mpl
- thrombopoietin receptor
- myeloproliferative leukemia virus oncogene
- thrombopoietin receptor-like
- cytokine receptor
- myeloproliferative leukemia virus oncogene, like
- thrombopoietin receptor c-mpl
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