MPL 抗体
(Myeloproliferative Leukemia Virus Oncogene (MPL))
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008].
recommended
recommended
recommended
MPL 适用: 人 WB, ELISA, FACS, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 1D6B7 unconjugated
MPL 抗体 by 适用
Find MPL 抗体 for a variety of species such as anti-Human MPL, anti-Mouse MPL, anti-Rat MPL. The species listed below are among those available. Click on a link to go to the corresponding products.
MPL 抗体 by 抗体来源
Find MPL 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
MPL 抗体 by 克隆形成能力
Find available monoclonal or polyclonal MPL 抗体. Click on a link to go to the corresponding products.
MPL 抗体 by 克隆
Find MPL 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.
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Cat. No.
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Quantity
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Cat. No.
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Quantity
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Quantity
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Cat. No.
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Cat. No.
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Quantity
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Quantity
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Datasheet
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Latest Publications for our MPL 抗体
: "Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis." in: Leukemia, (2017) (PubMed).: "Aerobic exercise in humans mobilizes HSCs in an intensity-dependent manner." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 122, Issue 1, pp. 182-190, (2017) (PubMed).
: "Mouse monoclonal antibodies against human c-Mpl and characterization for flow cytometry applications." in: Hybridoma (2005), Vol. 29, Issue 2, pp. 103-13, (2010) (PubMed).
: "Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 11781-91, (2009) (PubMed).
: "Genetic mutations associated with cigarette smoking in pancreatic cancer." in: Cancer research, Vol. 69, Issue 8, pp. 3681-8, (2009) (PubMed).
: "An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis." in: Blood, Vol. 92, Issue 6, pp. 1981-8, (1998) (PubMed).
: "Thrombopoietin and erythropoietin activate inside-out signaling of integrin and enhance adhesion to immobilized fibronectin in human growth-factor-dependent hematopoietic cells." in: Annals of hematology, Vol. 75, Issue 5-6, pp. 207-13, (1998) (PubMed).
: "Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit." in: Blood, Vol. 88, Issue 6, pp. 2026-32, (1996) (PubMed).
Aliases for MPL 抗体
MPL proto-oncogene, thrombopoietin receptor (MPL) 抗体myeloproliferative leukemia virus oncogene (Mpl) 抗体
MPL proto-oncogene, thrombopoietin receptor (Mpl) 抗体
MPL proto-oncogene, thrombopoietin receptor (mpl) 抗体
C-MPL 抗体
c-mpl 抗体
c-mpl-I 抗体
c-mpl-II 抗体
CD110 抗体
hlb219 抗体
MPL 抗体
mpll 抗体
MPLV 抗体
THCYT2 抗体
TPO-R 抗体
TPOR 抗体
tpor 抗体
tpor.b 抗体
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