MPL 抗体 (AA 401-500)
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- 抗原 See all MPL 抗体
- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
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抗原表位
- AA 401-500
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MPL antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 人, 小鼠
- 预测反应
- Rat,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human TPOR
- 亚型
- IgG
- Top Product
- Discover our top product MPL Primary Antibody
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anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 66-260) antibody
MPL 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) antibodyMPL 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 1H2 unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-175) antibodyMPL 适用: 人 WB, ELISA, FACS, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 1D6B7 unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 311-460) antibodyMPL 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-491) antibodyMPL 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (Internal Region) antibodyMPL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 1-635) antibodyMPL 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 1-635) antibodyMPL 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) antibodyMPL 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) antibodyMPL 适用: 人 WB, FACS, EIA 宿主: 小鼠 Monoclonal 1H2 unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
- 别名
- TPOR (MPL 产品)
- 别名
- C-MPL antibody, CD110 antibody, MPLV antibody, THCYT2 antibody, TPOR antibody, TPO-R antibody, c-mpl antibody, c-mpl-I antibody, c-mpl-II antibody, hlb219 antibody, MPL antibody, mpll antibody, tpor antibody, tpor.b antibody, MPL proto-oncogene, thrombopoietin receptor antibody, myeloproliferative leukemia virus oncogene antibody, MPL antibody, Mpl antibody, mpl antibody
- 背景
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Synonyms: C MPL, C-MPL, CMPL, CD110, CD 110, MPL, MPLV, Myeloprolerative leukemia protein, Myeloprolerative leukemia virus oncogene, Proto-oncogene c-Mpl, THCYT2, Thrombopoietin receptor, TPO R, TPO-R, TPOR, TPOR_HUMAN.
Background: Thrombopoietin (TPO or THPO), also known as c-Mpl ligand (c-Mpl L), is a cytokine that plays a central role in megakaryopoiesis by influencing the development and maturation of megakaryocytes and platelet production from hematopoietic stem cells. TPO exerts its biological effects through the TPO receptor, c-Mpl. c-Mpl is a member of the cytokine receptor superfamily. Expression of c-Mpl is restricted to hematopoietic tissues and cells, such as bone marrow, spleen, fetal liver and CD34+ cells. Stimulation of c-Mpl with TPO results in the activation of the Janus tyrosine kinase family members, Tyk 2 and JAK2, which in turn phosphorylate Stat5 and Stat3, causing their nuclear translocation and the transcription of Stat responsive genes. Muta-tions in c-Mpl have been implicated as the cause of certain human disorders, including congenital amegakaryocytic thrombocytopenia (CAMT) and thrombocytopenia with absent radii (TAR) syndrome.
- 途径
- JAK/STAT Signaling
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