MPL Protein (His tag)
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- 抗原 See all MPL 蛋白
- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
- 蛋白类型
- Recombinant
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宿主
- 大鼠
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资源
- Baculovirus infected Insect Cells
- 标记
- This MPL protein is labelled with His tag.
- 原理
- Recombinant Rat c-MPL/CD110/TPOR Protein (His Tag)
- 序列
- Met1-Ala500
- 产品特性
- A DNA sequence encoding the mature form of rat MPL (Met1-Ala500) was expressed with a polyhistide tag at the C-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
- Top Product
- Discover our top product MPL 蛋白
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Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-491) protein (His tag)
MPL 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-482) protein (His tag)MPL 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-635) protein (MBP tag,His tag)Crystallography grade MPL 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 1-635) protein (GST tag)MPL 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-491) protein (His tag)MPL 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, 10 % glycerol, pH 7.5
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
- 别名
- c-MPL/CD110/TPOR (MPL 产品)
- 别名
- C-MPL Protein, CD110 Protein, MPLV Protein, THCYT2 Protein, TPOR Protein, TPO-R Protein, c-mpl Protein, c-mpl-I Protein, c-mpl-II Protein, hlb219 Protein, MPL Protein, mpll Protein, tpor Protein, tpor.b Protein, MPL proto-oncogene, thrombopoietin receptor Protein, myeloproliferative leukemia virus oncogene Protein, MPL Protein, Mpl Protein, mpl Protein
- 背景
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Background: CD110, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number of cells of hematopoietic origin. C-MPL is homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. Thrombopoietin is the ligand for c-mpl. It was shown to be the major regulator of megakaryocytopoiesis and platelet formation. Defects in c-MPL are a cause of congenital amegakaryocytic thrombocytopeniawhich is a disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies. Defects in c-MPL also cause thrombocythemia type 2 and myelofibrosis with myeloid metaplasia.
Synonym: MPL
- 分子量
- 55.1 kDa
- 途径
- JAK/STAT Signaling
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