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MPL Protein (AA 22-489) (His tag)

MPL 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
产品编号 ABIN7454193
发货至: 中国
  • 抗原 See all MPL 蛋白
    MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
    蛋白类型
    Recombinant
    产品特性
    AA 22-489
    宿主
    • 11
    • 5
    • 1
    Cynomolgus
    资源
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    HEK-293 Cells
    标记
    This MPL protein is labelled with His tag.
    原理
    Cynomolgus c-MPL/Thrombopoietin R Protein
    序列
    Gln22-Thr489
    产品特性
    Recombinant Cynomolgus c-MPL/Thrombopoietin R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln22-Thr489.
    纯度
    > 95 % as determined by Tris-Bis PAGE
    过滤
    0.22 μm filtered
    内毒素水平
    Less than 1EU per μg by the LAL method.
    Biological Activity Comment
    Immobilized Cynomolgus c-MPL, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-C-MPL Antibody, hFc Tag with the EC50 of 12.7ng/ml determined by ELISA. See testing image for detail.
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    Discover our top product MPL 蛋白
  • 限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Supplied as 0.22μm filtered solution in 20 mM Tris, 500 mM NaCl, 3 mM DTT, 10 % Glycerol ( pH 7.5).
    储存液
    Dithiothreitol (DTT)
    注意事项
    This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -80 °C
    储存方法
    Valid for 12 months from date of receipt when stored at -80°C.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
    别名
    c-MPL (MPL 产品)
    别名
    C-MPL Protein, CD110 Protein, MPLV Protein, THCYT2 Protein, TPOR Protein, TPO-R Protein, c-mpl Protein, c-mpl-I Protein, c-mpl-II Protein, hlb219 Protein, MPL Protein, mpll Protein, tpor Protein, tpor.b Protein, MPL proto-oncogene, thrombopoietin receptor Protein, myeloproliferative leukemia virus oncogene Protein, MPL Protein, Mpl Protein, mpl Protein
    背景
    The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45 % of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML.
    分子量
    53.48 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
    UniProt
    A0A2K5UGC7
    途径
    JAK/STAT Signaling
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