Prolactin Receptor Protein (PRLR) (AA 25-234) (His tag)
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- 抗原 See all Prolactin Receptor (PRLR) 蛋白
- Prolactin Receptor (PRLR)
- 蛋白类型
- Recombinant
- 产品特性
- AA 25-234
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Prolactin Receptor protein is labelled with His tag.
- 原理
- Human PRLR Protein
- 序列
- Gln25-Asp234
- 产品特性
- Recombinant Human PRLR Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln25-Asp234.
- 纯度
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human PRLR, His Tag at 2μg/ml (100μl/Well) on the plate. Dose response curve for Anti-PRLR Antibody, hFc Tag with the EC50 of 78.7ng/ml determined by ELISA. The affinity constant of 0.96nM as determined in SPR assay (Biacore T200). See testing image for detail.
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Prolactin Receptor (PRLR) (AA 25-236) protein (His tag)
PRLR 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Prolactin Receptor (PRLR) (AA 20-229) protein (His tag)PRLR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Prolactin Receptor (PRLR) (AA 25-235) protein (Fc Tag)PRLR 宿主: 犬 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Prolactin Receptor (PRLR) (AA 25-234) (Active) protein (Fc Tag)PRLR 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Prolactin Receptor (PRLR) (AA 25-234) (Active) protein (His tag)PRLR 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Prolactin Receptor (PRLR) protein (Fc Tag)PRLR 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Prolactin Receptor (PRLR) (AA 371-479) protein (GST tag)PRLR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Prolactin Receptor (PRLR) (AA 1-622) protein (GST tag)PRLR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Prolactin Receptor (PRLR) protein (His tag)PRLR 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE
Prolactin Receptor (PRLR) protein (His tag,Fc Tag)PRLR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- 缓冲液
- Lyophilized from 0.22μm filtered solution in 50 mM Tris, 150nM Nacl ( pH 7.5). Normally 8 % trehalose is added as protectant before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- Prolactin Receptor (PRLR)
- 别名
- PRLR (PRLR 产品)
- 别名
- hPRLrI Protein, PRL-R Protein, prlr Protein, PRLRb Protein, PRLR Protein, tprlr Protein, DKFZp469D061 Protein, RATPRLR Protein, AI987712 Protein, Pr-1 Protein, Pr-3 Protein, Prlr-rs1 Protein, wu:fj65c07 Protein, prolactin receptor Protein, prolactin receptor L homeolog Protein, prolactin receptor S homeolog Protein, prolactin receptor a Protein, PRLR Protein, prlr.L Protein, prlr.S Protein, PR Protein, prlr Protein, Prlr Protein, prlra Protein
- 背景
- Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers.
- 分子量
- 25.5 kDa. Due to glycosylation, the protein migrates to 35-40 kDa based on Tris-Bis PAGE result.
- 途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus
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