Prolactin Receptor Protein (PRLR) (His tag)
-
- 抗原 See all Prolactin Receptor (PRLR) 蛋白
- Prolactin Receptor (PRLR)
- 蛋白类型
- Recombinant
-
宿主
- 大鼠
-
资源
- HEK-293 Cells
- 标记
- This Prolactin Receptor protein is labelled with His tag.
- 原理
- Recombinant Rat PRLR/Prolactin Receptor Protein (His Tag)
- 序列
- Met 1-Asp 229
- 产品特性
- A DNA sequence encoding the rat PRLR (P05710-1) extracellular domain (Met 1-Asp 229) was expressed, fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 97 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
- Top Product
- Discover our top product PRLR 蛋白
-
Prolactin Receptor (PRLR) (AA 25-234) protein (His tag)
PRLR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Prolactin Receptor (PRLR) (AA 25-236) protein (His tag)PRLR 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Prolactin Receptor (PRLR) (AA 20-229) protein (His tag)PRLR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Prolactin Receptor (PRLR) (AA 25-235) protein (Fc Tag)PRLR 宿主: 犬 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Prolactin Receptor (PRLR) (AA 25-234) (Active) protein (Fc Tag)PRLR 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Prolactin Receptor (PRLR) (AA 25-234) (Active) protein (His tag)PRLR 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Prolactin Receptor (PRLR) protein (Fc Tag)PRLR 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Prolactin Receptor (PRLR) (AA 371-479) protein (GST tag)PRLR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Prolactin Receptor (PRLR) (AA 1-622) protein (GST tag)PRLR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Prolactin Receptor (PRLR) protein (His tag,Fc Tag)PRLR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- Prolactin Receptor (PRLR)
- 别名
- PRLR/Prolactin Receptor (PRLR 产品)
- 别名
- hPRLrI Protein, PRL-R Protein, prlr Protein, PRLRb Protein, PRLR Protein, tprlr Protein, DKFZp469D061 Protein, RATPRLR Protein, AI987712 Protein, Pr-1 Protein, Pr-3 Protein, Prlr-rs1 Protein, wu:fj65c07 Protein, prolactin receptor Protein, prolactin receptor L homeolog Protein, prolactin receptor S homeolog Protein, prolactin receptor a Protein, PRLR Protein, prlr.L Protein, prlr.S Protein, PR Protein, prlr Protein, Prlr Protein, prlra Protein
- 背景
-
Background: Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type â… cytokine receptor superfamily, and contains two fibronectin type-â…¢ domains. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules invloved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. PRLR mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLR). Ubiquitin-dependent degradation of the PRLR that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast cancer.
Synonym: MGC105486;RATPRLR
- 分子量
- 26 kDa
- 途径
- JAK/STAT Signaling, Response to Growth Hormone Stimulus
-
