LAG3 Protein (AA 23-434) (His tag)
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- 抗原 See all LAG3 蛋白
- LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
- 蛋白类型
- Recombinant
- 产品特性
- AA 23-434
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This LAG3 protein is labelled with His tag.
- 原理
- Human LAG3/CD223 Protein
- 序列
- Leu23-Gly434
- 产品特性
- Recombinant Human LAG3/CD223 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu23-Gly434.
- 纯度
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human LAG3, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-LAG3 Antibody, hFc Tag with the EC50 of 9.1ng/ml determined by ELISA. See testing image for detail.
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Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) protein (Fc Tag)
LAG3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Lymphocyte-Activation Gene 3 (LAG3) (AA 23-434) protein (His-Avi Tag,Biotin)LAG3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lymphocyte-Activation Gene 3 (LAG3) protein (His tag)LAG3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE
Lymphocyte-Activation Gene 3 (LAG3) (AA 18-449) (Active) protein (Fc Tag)LAG3 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Lymphocyte-Activation Gene 3 (LAG3) (AA 23-450) (Active) protein (His tag)LAG3 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Lymphocyte-Activation Gene 3 (LAG3) (Active) protein (His tag)LAG3 宿主: Cynomolgus 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Lymphocyte-Activation Gene 3 (LAG3) (AA 23-222) protein (His-IF2DI Tag)LAG3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Lymphocyte-Activation Gene 3 (LAG3) (Active) protein (His tag)LAG3 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE Active
Lymphocyte-Activation Gene 3 (LAG3) protein (Fc Tag)LAG3 宿主: Cynomolgus 宿主: 人细胞 Recombinant > 90 % as determined by reducing SDS-PAGE.
Lymphocyte-Activation Gene 3 (LAG3) (AA 1-360) protein (GST tag)LAG3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- 缓冲液
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- LAG3 (Lymphocyte-Activation Gene 3 (LAG3))
- 别名
- LAG3 (LAG3 产品)
- 别名
- CD223 Protein, LAG-3 Protein, Ly66 Protein, lymphocyte activating 3 Protein, lymphocyte-activation gene 3 Protein, LAG3 Protein, Lag3 Protein
- 背景
- LAG-3, is a protein which in humans is encoded by the LAG3 gene, which is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders.
- 分子量
- 45.5 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.
- 途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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