IL3RA Protein (His tag,ECD)
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- 抗原 See all IL3RA 蛋白
- IL3RA (Interleukin 3 Receptor, alpha (IL3RA))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This IL3RA protein is labelled with His tag,ECD.
- 原理
- Recombinant Mouse CD123/IL3RA Protein (ECD, His Tag)
- 序列
- Met1-Lys331
- 产品特性
- A DNA sequence encoding the mouse Il3ra (EDL20630.1) (Met1-Lys331) was expressed with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product IL3RA 蛋白
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Interleukin 3 Receptor, alpha (IL3RA) (AA 19-305) protein (Fc Tag)
IL3RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Interleukin 3 Receptor, alpha (IL3RA) (AA 19-305) protein (His tag)IL3RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 3 Receptor, alpha (IL3RA) (AA 18-302) protein (His tag)IL3RA 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 3 Receptor, alpha (IL3RA) (AA 19-305) protein (His-Avi Tag,Biotin)IL3RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 3 Receptor, alpha (IL3RA) (AA 19-305) protein (His-DYKDDDDK-Strep II Tag)IL3RA 宿主: 人 宿主: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Interleukin 3 Receptor, alpha (IL3RA) protein (Fc Tag)IL3RA 宿主: Cynomolgus 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Interleukin 3 Receptor, alpha (IL3RA) protein (Fc-His Tag)IL3RA 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Interleukin 3 Receptor, alpha (IL3RA) (AA 19-109) protein (GST tag)IL3RA 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 3 Receptor, alpha (IL3RA) (AA 19-305) (Active) protein (His tag,AVI tag,Biotin)IL3RA 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- IL3RA (Interleukin 3 Receptor, alpha (IL3RA))
- 别名
- CD123/IL3RA (IL3RA 产品)
- 别名
- CD123 Protein, IL3R Protein, IL3RAY Protein, IL3RX Protein, IL3RY Protein, hIL-3Ra Protein, CDw123 Protein, SUT-1 Protein, Cyrl Protein, interleukin 3 receptor subunit alpha Protein, interleukin 3 receptor, alpha chain Protein, IL3RA Protein, Il3ra Protein
- 背景
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Background: Interleukin-3 receptor subunit alpha, also known as IL-3 receptor subunit alpha, IL-3R-alpha, CD123, and IL3RA, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and Type 5 subfamily. The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. The WSXWS motif of IL3RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box one motif of IL3RA is required for JAK interaction and / or activation. IL3RA represents a unique marker for primitive leukemic stem cells. Targeting of IL3RA may be a promising strategy for the preferential ablation of AML cells. Aberrant IL3RA expression is a good marker for monitoring of minimal residual disease. IL3RA is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. Recent studies have shown that interleukin-3 receptor alpha (CD123) is highly expressed on leukemia stem cells of patients with acute myeloid leukemia, and is correlated with tumor load and poor prognosis. CD123 was highly expressed in the bone marrow of the patients with myelodysplastic syndrome (MDS), significantly correlated with the proportion of bone marrow blasts, and thus might be the marker of MDS malignant clone. IL3RA is also a useful new marker for distinguishing B-cell disorders with circulating villous lymphocytes as its expression is characteristic of typical hairy cell leukemia (HCL) with high sensitivity and specificity.
Synonym: CD123,CDw123,SUT-1
- 分子量
- 35.9 kDa
- 途径
- JAK/STAT Signaling
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