TIM3 Protein (AA 1-191) (His tag)
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- 抗原 See all TIM3 (TIM 3) 蛋白
- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-191
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This TIM3 protein is labelled with His tag.
- 原理
- Recombinant Mouse TIM-3/HAVCR2 Protein (aa 1-191, His Tag)
- 序列
- Met1-Arg191
- 产品特性
- A DNA sequence encoding the mouse HAVCR2 (AAL65156.1) (Met1-Arg191) was expressed with a C-terminal polyhistidine tag.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product TIM 3 蛋白
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Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-200) protein (His tag)
TIM 3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-200) protein (His-Avi Tag,Biotin)TIM 3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-191) protein (His tag)TIM 3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Hepatitis A Virus Cellular Receptor 2 (TIM 3) protein (mFc-His Tag)TIM 3 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-200) (Active) protein (His tag,AVI tag,Biotin)TIM 3 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Hepatitis A Virus Cellular Receptor 2 (TIM 3) protein (His tag)TIM 3 宿主: Marmoset 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 20-191) protein (His tag)TIM 3 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Hepatitis A Virus Cellular Receptor 2 (TIM 3) (Active) protein (Fc Tag)TIM 3 宿主: 小鼠 宿主: 人细胞 Recombinant > 90 % as determined by reducing SDS-PAGE. Active
Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 20-193) protein (His tag)TIM 3 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Hepatitis A Virus Cellular Receptor 2 (TIM 3) protein (Fc Tag)TIM 3 宿主: Cynomolgus 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
- 别名
- TIM-3/HAVCR2 (TIM 3 产品)
- 别名
- HAVCR2 Protein, MGC140131 Protein, HAVcr-2 Protein, KIM-3 Protein, TIM3 Protein, TIMD-3 Protein, TIMD3 Protein, Tim-3 Protein, TIM-3 Protein, Tim3 Protein, Timd3 Protein, tim3 Protein, hepatitis A virus cellular receptor 2 Protein, HAVCR2 Protein, Havcr2 Protein
- 物质类
- Virus
- 背景
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Background: Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In tumor rejection model, soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.Immune CheckpointImmune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IP Antibodies Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: Hepatitis A virus cellular receptor 2 homolog;HAVcr-2;T-cell immunoglobulin and mucin domain-containing protein 3;T-cell immunoglobulin mucin receptor 3;T-cell membrane protein 3;Tim3; Timd3
- 分子量
- 20.3 kDa
- 途径
- Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
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