TIM3 Protein (AA 20-193) (His tag)
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- 抗原 See all TIM3 (TIM 3) 蛋白
- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
- 蛋白类型
- Recombinant
- 产品特性
- AA 20-193
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宿主
- 小鼠
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资源
- 人细胞
- 标记
- This TIM3 protein is labelled with His tag.
- 原理
- Recombinant Mouse TIM-3/HAVCR2 Protein (aa 20-193, His Tag)
- 序列
- Arg20-Ala193
- 产品特性
- Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3 is produced by our Mammalian expression system and the target gene encoding Arg20-Ala193 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product TIM 3 蛋白
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Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-200) protein (His tag)
TIM 3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-200) protein (His-Avi Tag,Biotin)TIM 3 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-191) protein (His tag)TIM 3 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Hepatitis A Virus Cellular Receptor 2 (TIM 3) protein (mFc-His Tag)TIM 3 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 22-200) (Active) protein (His tag,AVI tag,Biotin)TIM 3 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Hepatitis A Virus Cellular Receptor 2 (TIM 3) protein (His tag)TIM 3 宿主: Marmoset 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 20-191) protein (His tag)TIM 3 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Hepatitis A Virus Cellular Receptor 2 (TIM 3) (Active) protein (Fc Tag)TIM 3 宿主: 小鼠 宿主: 人细胞 Recombinant > 90 % as determined by reducing SDS-PAGE. Active
Hepatitis A Virus Cellular Receptor 2 (TIM 3) protein (Fc Tag)TIM 3 宿主: Cynomolgus 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Hepatitis A Virus Cellular Receptor 2 (TIM 3) (AA 1-142) protein (GST tag)TIM 3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
- 别名
- TIM-3/HAVCR2 (TIM 3 产品)
- 别名
- HAVCR2 Protein, MGC140131 Protein, HAVcr-2 Protein, KIM-3 Protein, TIM3 Protein, TIMD-3 Protein, TIMD3 Protein, Tim-3 Protein, TIM-3 Protein, Tim3 Protein, Timd3 Protein, tim3 Protein, hepatitis A virus cellular receptor 2 Protein, HAVCR2 Protein, Havcr2 Protein
- 物质类
- Virus
- 背景
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Background: T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.
Synonym: Hepatitis A virus cellular receptor 2 homolog,HAVcr-2,T-cell immunoglobulin and mucin domain-containing protein 3,T-cell immunoglobulin mucin receptor 3,T-cell membrane protein 3,Tim3, Timd3
- 分子量
- 19.9 kDa
- 途径
- Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
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