2B4 Protein (AA 20-225) (Fc Tag)
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- 抗原 See all 2B4 (CD244) 蛋白
- 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))
- 蛋白类型
- Recombinant
- 产品特性
- AA 20-225
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This 2B4 protein is labelled with Fc Tag.
- 原理
- Recombinant mouse 2B4 protein with C-terminal human Fc tag
- 特异性
- Mouse 2B4 (Gln20-Leu225) hFc (Glu99-Ala330)
- 产品特性
- Extracellular Domain Protein
- 纯化方法
- Purified from cell culture supernatant by affinity chromatography
- 纯度
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product CD244 蛋白
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Natural Killer Cell Receptor 2B4 (CD244) (AA 22-221) protein (His tag)
CD244 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Natural Killer Cell Receptor 2B4 (CD244) (AA 22-221) protein (Fc Tag)CD244 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Natural Killer Cell Receptor 2B4 (CD244) (AA 22-221) protein (His-Avi Tag,Biotin)CD244 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Natural Killer Cell Receptor 2B4 (CD244) (AA 22-221) protein (mFc-His Tag)CD244 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Natural Killer Cell Receptor 2B4 (CD244) (AA 22-221) protein (His tag,AVI tag,Biotin)CD244 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Natural Killer Cell Receptor 2B4 (CD244) protein (His tag)CD244 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Natural Killer Cell Receptor 2B4 (CD244) (AA 125-224) protein (GST tag)CD244 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Natural Killer Cell Receptor 2B4 (CD244) (AA 1-365) protein (GST tag)CD244 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Natural Killer Cell Receptor 2B4 (CD244) (AA 22-221) (Active) protein (Fc Tag)CD244 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))
- 别名
- 2B4 (CD244 产品)
- 别名
- CD244 Protein, 2B4 Protein, NAIL Protein, NKR2B4 Protein, Nmrk Protein, SLAMF4 Protein, C9.1 Protein, F730046O15Rik Protein, Ly90 Protein, CD244 molecule Protein, CD244 natural killer cell receptor 2B4 Protein, CD244 Protein, Cd244 Protein
- 背景
- Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family, its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:8326140, PubMed:12734329, PubMed:19648922, PubMed:20962259). Activating function implicates association with SH2D1A and FYN. Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2. Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8326140, PubMed:15169881, PubMed:15998796, PubMed:22683124). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (PubMed:15905190). Regulation of NK cell activity by adapters Sh2d1b and Sh2d1b2 is reported conflictingly (PubMed:16127454, PubMed:16425036). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1. At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (By similarity). Involved in the regulation of CD8( ) T-cell proliferation, expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells (PubMed:11739483). Inhibits inflammatory responses in dendritic cells (DCs) (PubMed:25643613).[UniProtKB/Swiss-Prot Function]
- 分子量
- predicted molecular mass of 49.4 kDa after removal of the signal peptide.The apparent molecular mass of m2B4-hFc is 55-100 kDa due to glycosylation.
- UniProt
- Q07763
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