TIGIT Protein (partial) (Fc Tag)
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- 抗原 See all TIGIT 蛋白
- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- partial
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宿主
- 兔
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资源
- HEK-293 Cells
- 标记
- This TIGIT protein is labelled with Fc Tag.
- 应用范围
- Western Blotting (WB), ELISA
- 序列
- Ala 16 - Pro 142
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Endotoxin level is less than 1.0 EU per ug by the LAL method.
- Biological Activity Comment
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Measured by its binding ability in a functional ELISA. Immobilized Human Nectin-2, His Tag at 5 μg/mL (100 uL/well) can bind Rabbit TIGIT, Fc Tag with a linear range of 5-78 ng/mL (QC tested).
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T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) protein (Fc Tag)
TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) protein (His tag)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) protein (His-Avi Tag,Biotin)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 26-143) protein (Fc Tag)TIGIT 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 26-143) protein (His tag)TIGIT 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) protein (His tag)TIGIT 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) protein (mFc Tag)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 89-208) (Active) protein (His tag)TIGIT 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Func Active
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) (Active) protein (Fc Tag)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) (Active) protein (Fc Tag,AVI tag,Biotin)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
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- 应用备注
- This recombinant protein can be used for E, WB.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- 50 mM Tris, 100 mM Glycine, pH 7.5
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.
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- 抗原
- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
- 别名
- TIGIT (TIGIT 产品)
- 别名
- VSIG9 Protein, VSTM3 Protein, WUCAM Protein, ENSMUSG00000071552 Protein, Vstm3 Protein, RGD1563191 Protein, T-cell immunoreceptor with Ig and ITIM domains Protein, T cell immunoreceptor with Ig and ITIM domains Protein, TIGIT Protein, Tigit Protein
- 背景
- T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
- 分子量
- 40.4 kDa
- 基因ID
- 100343230
- UniProt
- G1SLC1
- 途径
- Cancer Immune Checkpoints
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