TIGIT Protein (AA 22-138, Extracellular Domain) (Fc Tag)
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- 抗原 See all TIGIT 蛋白
- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
- 蛋白类型
- Recombinant
- 产品特性
- AA 22-138, Extracellular Domain
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This TIGIT protein is labelled with Fc Tag.
- 应用范围
- SDS-PAGE (SDS)
- 交叉反应
- 人
- 产品特性
- The extracellular domain of human TIGIT (aa 22-138) is fused at the C-terminus to the Fc portion of human IgG1.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product TIGIT 蛋白
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T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) protein (Fc Tag)
TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) protein (His tag)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) protein (His-Avi Tag,Biotin)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 26-143) protein (Fc Tag)TIGIT 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 26-143) protein (His tag)TIGIT 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) protein (His tag)TIGIT 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) protein (mFc Tag)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 89-208) (Active) protein (His tag)TIGIT 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Func Active
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) (Active) protein (Fc Tag)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) (Active) protein (Fc Tag,AVI tag,Biotin)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Solid
- 浓度
- Lot specific
- 缓冲液
- Lyophilized. Contains PBS.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - 有效期
- 6 months
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- 抗原
- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
- 别名
- TIGIT (TIGIT 产品)
- 别名
- VSIG9 Protein, VSTM3 Protein, WUCAM Protein, ENSMUSG00000071552 Protein, Vstm3 Protein, RGD1563191 Protein, T-cell immunoreceptor with Ig and ITIM domains Protein, T cell immunoreceptor with Ig and ITIM domains Protein, TIGIT Protein, Tigit Protein
- 背景
- TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a novel member of the immunoglobulin super family (IgSF). TIGIT and CD226 bind the same ligands, the two nectin-family members poliovirus receptor (PVR) and poliovirus receptor-related 2 (CD112) and compete for each other. TIGIT inhibits while CD226 activates the signaling through PVR and CD112. TIGIT and CD226 directly interact at the cell surface and this interaction impairs CD226 homodimerization and function. TIGIT is absent on naive T cells, but is expressed on activated Tregs and memory T cells, and on NK cells and NKT cells. TIGIT negatively regulates T cell activation and blockade of TIGIT exacerbates several immune diseases. TIGIT also activates the PVR receptor on dendritic cells (DCs). Addition of TIGIT (human):Fc (human) to DCs triggers phosphorylation of PVR and elicits downstream signaling, which then inhibits T cell responses by producing IL-10. TIGIT also negatively regulates NK cell cytotoxicity and cytokine production. TIGIT is directly regulated by FoxP3 and promotes inducible Treg differentiation.
- 分子量
- ~40-45kDa (SDS-PAGE)
- UniProt
- Q495A1
- 途径
- Cancer Immune Checkpoints
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