TIGIT Protein (AA 22-141) (Fc Tag)
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- 抗原 See all TIGIT 蛋白
- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 22-141
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This TIGIT protein is labelled with Fc Tag.
- 应用范围
- Functional Studies (Func)
- 序列
- AA 22-141
- 产品特性
- This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.1 kDa. The protein migrates as 42-50 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 0.1 EU per μg by the LAL method.
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- Discover our top product TIGIT 蛋白
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T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) protein (Fc Tag)
TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) protein (His tag)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) protein (His-Avi Tag,Biotin)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 26-143) protein (Fc Tag)TIGIT 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 26-143) protein (His tag)TIGIT 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) protein (His tag)TIGIT 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) protein (mFc Tag)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 89-208) (Active) protein (His tag)TIGIT 宿主: Cynomolgus, 猕猴 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Func Active
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) (Active) protein (Fc Tag)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) (AA 22-141) (Active) protein (Fc Tag,AVI tag,Biotin)TIGIT 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Tris with Glycine, Arginine and NaCl, pH 7.5
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
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- 抗原
- TIGIT (T Cell Immunoreceptor with Ig and ITIM Domains (TIGIT))
- 别名
- TIGIT (TIGIT 产品)
- 别名
- VSIG9 Protein, VSTM3 Protein, WUCAM Protein, ENSMUSG00000071552 Protein, Vstm3 Protein, RGD1563191 Protein, T-cell immunoreceptor with Ig and ITIM domains Protein, T cell immunoreceptor with Ig and ITIM domains Protein, TIGIT Protein, Tigit Protein
- 背景
- TIGIT (also called T cell immunoreceptor with Ig and ITIM domains) is one newly discovered immune receptor on some percentage of T cells and Natural Killer Cells(NK). It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155(PVR) on dendritic cells(DCs), macrophages, etc. with high affinity, and also to CD112(PVRL2) with lower affinity. TIGIT expressing CD8+ T cells has been shown to be expanded and associated with clinical markers of HIV disease progression in a diverse group of HIV infected individuals. TIGIT and PD-1 has been shown to be over expressed on tumor antigen-sepcific (TA-specific) CD8+ T cells and CD8+ tumor infiltrating lymphocytes (TILs) from individuals with melanoma. Blockade of TIGIT and PD-1 led to increased cell proliferation, cytokine production, and degranulation of TA-specific CD8+ T cells and TIL CD8+ T cells.
- 分子量
- 40.1 kDa
- 途径
- Cancer Immune Checkpoints
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