Growth Hormone Receptor Protein (GHR) (AA 27-264) (His tag)
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- 抗原 See all Growth Hormone Receptor (GHR) 蛋白
- Growth Hormone Receptor (GHR)
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 27-264
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Growth Hormone Receptor protein is labelled with His tag.
- 序列
- AA 27-264
- 产品特性
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.5 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- 纯度
- >90 % as determined by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product GHR 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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Nanofluidic device for continuous multiparameter quality assurance of biologics." in: Nature nanotechnology, Vol. 12, Issue 8, pp. 804-812, (2019) (PubMed).
: "Mechanism of immobilized protein A binding to immunoglobulin G on nanosensor array surfaces." in: Analytical chemistry, Vol. 87, Issue 16, pp. 8186-93, (2015) (PubMed).
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Nanofluidic device for continuous multiparameter quality assurance of biologics." in: Nature nanotechnology, Vol. 12, Issue 8, pp. 804-812, (2019) (PubMed).
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- 抗原
- Growth Hormone Receptor (GHR)
- 别名
- Growth Hormone R (GHR 产品)
- 别名
- GHBP Protein, AA986417 Protein, GHR/BP Protein, GHR Protein, ghr Protein, ghr.a Protein, zgc:162141 Protein, growth hormone receptor Protein, growth hormone receptor L homeolog Protein, growth hormone receptor a Protein, GHR Protein, Ghr Protein, ghr.L Protein, ghr Protein, ghra Protein
- 背景
- Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
- 分子量
- 29.6 kDa
- NCBI登录号
- NP_000154
- UniProt
- P10912
- 途径
- NF-kappaB Signaling, JAK/STAT Signaling, Response to Growth Hormone Stimulus
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