Growth Hormone Receptor Protein (GHR) (His tag,Fc Tag)
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- 抗原 See all Growth Hormone Receptor (GHR) 蛋白
- Growth Hormone Receptor (GHR)
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This Growth Hormone Receptor protein is labelled with His tag,Fc Tag.
- 原理
- Recombinant Mouse GHR/GHBP Protein (His & Fc Tag)(Active)
- 序列
- Met 1-Gln 273
- 产品特性
- A DNA sequence encoding the extracellular domain (Met 1-Gln 273) of mouse GHR (NP_034414.2) precursor was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.
- 纯度
- > 85 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit proliferation of INS-1 cells induced by human growth hormone. The ED50 for this effect is 0.5-2 μg/mL in the presence of 50 ng/mL human growth hormone.
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- Discover our top product GHR 蛋白
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Growth Hormone Receptor (GHR) (AA 27-264) protein (His tag)
GHR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Growth Hormone Receptor (GHR) (AA 27-264) (Active) protein (His tag)GHR 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Growth Hormone Receptor (GHR) protein (Fc Tag)GHR 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Growth Hormone Receptor (GHR) (AA 19-118) protein (GST tag)GHR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Growth Hormone Receptor (GHR) (Active) protein (His tag)GHR 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Growth Hormone Receptor (GHR) (Active) protein (Fc Tag)GHR 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Growth Hormone Receptor (GHR) (Active) protein (His tag)GHR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Growth Hormone Receptor (GHR) (AA 289-638) protein (His tag)Crystallography grade GHR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Growth Hormone Receptor (GHR) (AA 25-273) protein (His tag)Crystallography grade GHR 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Growth Hormone Receptor (GHR) (AA 298-650) protein (His tag)Crystallography grade GHR 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- Growth Hormone Receptor (GHR)
- 别名
- GHR/GHBP (GHR 产品)
- 别名
- GHBP Protein, AA986417 Protein, GHR/BP Protein, GHR Protein, ghr Protein, ghr.a Protein, zgc:162141 Protein, growth hormone receptor Protein, growth hormone receptor L homeolog Protein, growth hormone receptor a Protein, GHR Protein, Ghr Protein, ghr.L Protein, ghr Protein, ghra Protein
- 背景
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Background: Growth hormone receptor, also known as GH receptor and GHR, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and type 1 subfamily. GHR contains one fibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression of GHR in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform 2 of GHR up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.
Synonym: Growth Hormone Receptor;GHBP;GHR/BP
- 分子量
- 56.8 kDa
- NCBI登录号
- NP_034414
- 途径
- NF-kappaB Signaling, JAK/STAT Signaling, Response to Growth Hormone Stimulus
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